533657 PI4KIIIβ Inhibitor, BF738735 - Calbiochem

533657
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical Formula
      C₂₁H₁₉FN₄O₃S

      Pricing & Availability

      Catalog Number AvailabilityPackaging Qty/Pack Price Quantity
      5.33657.0001
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          Glass bottle 10 mg
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          Description
          OverviewA cell-permeable imidazo-pyrazine based compound that acts as a potent and reversible inhibitor of PI4KIIIβ (IC50 = 5.7 nM). Displays excellent selectivity over PI4KIIIα (IC50 = 1.7 µM) and several other lipid kinases (IC50 > 10 µM). Shown to dose-dependently decrease PI4P levels, reduce oxysterol-binding protein (OSBP) localization to replication organelles (ROs) and inhibit cholesterol shuttling to ROs (at 1 µM in BGM and HeLaR19 cells transfected with CVB3) at multiplicity of infection (MOI). Exhibits uniformly potent and broad spectrum antienteroviral activity across a wide range of species (EC50 = 4-31 nM) and is inactive against RNA, DNA, and retroviruses.
          Catalogue Number533657
          Brand Family Calbiochem®
          Synonyms2-Fluoro-4-(2-methyl-8-(3-(methylsulfonyl)benzylamino)imidazo[1,2-a]pyrazin-3-yl)phenol, Phosphatidylinositol-phosphate-4-Kinase III β Inhibitor, BF-738735
          DescriptionPI4KIIIβ Inhibitor, BF738735
          References
          ReferencesStrating, J.R.P.M., et al. 2015. Cell Reports. 10, 600.
          MacLeod, A.M., et al. 2013. ACS Med. Chem. Lett. 4, 585.
          Product Information
          FormLight grey powder
          Hill FormulaC₂₁H₁₉FN₄O₃S
          Chemical formulaC₂₁H₁₉FN₄O₃S
          ReversibleY
          Applications
          Biological Information
          Primary TargetPI4KIII&beta
          Primary Target IC<sub>50</sub>5.7 nM
          Purity≥98% by HPLC
          Physicochemical Information
          Cell permeableY
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage +2°C to +8°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          PI4KIIIβ Inhibitor, BF738735 - Calbiochem SDS

          Title

          Safety Data Sheet (SDS) 

          References

          Reference overview
          Strating, J.R.P.M., et al. 2015. Cell Reports. 10, 600.
          MacLeod, A.M., et al. 2013. ACS Med. Chem. Lett. 4, 585.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision24-June-2016 JSW
          Synonyms2-Fluoro-4-(2-methyl-8-(3-(methylsulfonyl)benzylamino)imidazo[1,2-a]pyrazin-3-yl)phenol, Phosphatidylinositol-phosphate-4-Kinase III β Inhibitor, BF-738735
          DescriptionA cell-permeable imidazo-pyrazine based compound that acts as a potent and reversible inhibitor of PI4KIIIβ (IC50 = 5.7 nM). Displays excellent selectivity over PI4KIIIα (IC50 = 1.7 µM) and several other lipid kinases (IC50 > 10 µM). Shown to dose-dependently decrease PI4P levels, reduce oxysterol-binding protein (OSBP) localization to replication organelles (ROs) and inhibit cholesterol shuttling to ROs (at 1 µM in BGM and HeLaR19 cells transfected with CVB3) at multiplicity of infection (MOI). Exhibits uniformly potent and broad spectrum antienteroviral activity across a wide range of species (EC50 = 4-31 nM) and is inactive against RNA, DNA, and retroviruses.
          FormLight grey powder
          Intert gas (Yes/No) Packaged under inert gas
          Chemical formulaC₂₁H₁₉FN₄O₃S
          Purity≥98% by HPLC
          SolubilityDMSO (50 mg/ml)
          Storage +2°C to +8°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Standard Handling
          ReferencesStrating, J.R.P.M., et al. 2015. Cell Reports. 10, 600.
          MacLeod, A.M., et al. 2013. ACS Med. Chem. Lett. 4, 585.