33-041 PI 3-Kinase 3-step HTRF™ Assay

33-041
1920 wells  Kit capacity: 1920 wells
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      Overview

      Replacement Information

      Key Specifications Table

      Species ReactivityKey ApplicationsAnalytes AvailableDetection Methods
      H, M KA PI 3-Kinase HTRF
      Description
      Catalogue Number33-041
      Brand Family Upstate
      Trade Name
      • HTRF
      • Upstate
      DescriptionPI 3-Kinase 3-step HTRF™ Assay
      References
      Product Information
      Components
      • 4X Reaction Buffer
      • PIP2 (substrate, 1mM stock)
      • DM A Reaction Buffer
      • DM B Reaction Buffer
      • DM C Reaction Buffer
      • BPIP3
      • Stop Reagent
      Detection methodHTRF
      Applications
      ApplicationEverything you need to perform the PI3 Kinase 3-step HTRF assays (1920 wells).
      Key Applications
      • Kinase Assay
      Biological Information
      Species Reactivity
      • Human
      • Mouse
      Analytes Available
      • PI 3-Kinase
      Entrez Gene Number
      Entrez Gene SummaryPhosphatidylinositol 3-kinase is composed of an 85 kDa regulatory subunit and a 110 kDa catalytic subunit. The protein encoded by this gene represents the catalytic subunit, which uses ATP to phosphorylate PtdIns, PtdIns4P and PtdIns(4,5)P2. This gene has been found to be oncogenic and has been implicated in cervical cancers.
      Gene Symbol
      • PIK3CA
      • MGC142163
      • PI3K
      • MGC142161
      • p110-alpha
      Target Sub-FamilyPI3K/PI4K
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: P42336 # Phosphorylates PtdIns, PtdIns4P and PtdIns(4,5)P2 with a preference for PtdIns(4,5)P2.
      SIZE: 1068 amino acids; 124284 Da
      SUBUNIT: Heterodimer of a p110 (catalytic) and a p85 (regulatory) subunit. Binds to IRS1 in nuclear extracts. Interacts with RUFY3 (By similarity).
      DISEASE: SwissProt: P42336 # Defects in PIK3CA are associated with colorectal cancer (CRC) [MIM:114500]. & Defects in PIK3CA are associated with breast cancer [MIM:114480]. & Defects in PIK3CA are associated with epithelial ovarian cancer (EOC) [MIM:604370].
      SIMILARITY: SwissProt: P42336 ## Belongs to the PI3/PI4-kinase family. & Contains 1 C2 domain. & Contains 1 PI3K/PI4K domain.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage Conditions12 months at -70°C
      Packaging Information
      Material Size1920 wells
      Material PackageKit capacity: 1920 wells
      Transport Information
      Supplemental Information
      Specifications

      Related Products & Applications

      Alternative Packsize

      Catalog Number Description  
      33-040 PI 3-Kinase 3-step HTRF™ Assay Show Pricing & Availability
      33-047 PI 3-Kinase 3-step HTRF™ Assay Show Pricing & Availability

      Alternative Format

      Catalog Number Description  
      33-017 PI 3-Kinase HTRF™ Assay; 1920 wells Show Pricing & Availability

      Product Families

      Related Products By: Brand Facete

      Categories

      Life Science Research > Protein Detection and Quantification > Activity Assays > Kinase Assays