496100 Omeprazole - CAS 73590-58-6 - Calbiochem

496100
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₁₇H₁₉N₃O₃S 73590-58-6

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      496100-50MG
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          Plastic ampoule 50 mg
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          Description
          OverviewA cell-permeable pyridyl methylsulfinyl benzimidazole compound that acts as selective proton pump inhibitor. Behaves as a prodrug by undergoing an acid-catalyzed rearrangement to a thiol-reactive cationic sulfenamide that inhibits (H+, K+)-ATPase in the gastric milieu. An aryl hydrocarbon-like inducer of cytochrome P450 secretion in human liver.
          Catalogue Number496100
          Brand Family Calbiochem®
          SynonymsH 168/68, 5-Methoxy-2[(4-methoxy-3,5-dimethyl-2-pyridyl)methylsulfinyl]-1H-benzimidazole
          References
          ReferencesLambrecht, N., et al. 2000. J. Biol. Chem. 275, 4041.
          Besancon, M., et al. 1997. J. Biol. Chem. 272, 22438.
          Sachs, G., et al. 1995. Ann. Rev. Pharmacol. Toxicol. 35, 277.
          Diaz, D., et al. 1990. Gastroenterology 99, 737.
          Fellenius, E., et al. 1981. Nature 290, 159.
          Product Information
          CAS number73590-58-6
          ATP CompetitiveN
          FormTan to off-white solid
          Hill FormulaC₁₇H₁₉N₃O₃S
          Chemical formulaC₁₇H₁₉N₃O₃S
          ReversibleN
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Primary Targetproton pump
          Purity≥94% by HPLC
          Physicochemical Information
          Cell permeableY
          ContaminantsHeavy metals: ≤20 ppm
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          RTECSDD9087000
          Safety Information
          R PhraseR: 36/37/38

          Irritating to eyes, respiratory system and skin.
          S PhraseS: 26-36

          In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
          Wear suitable protective clothing.
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Irritant
          Storage +2°C to +8°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          496100

          References

          Reference overview
          Lambrecht, N., et al. 2000. J. Biol. Chem. 275, 4041.
          Besancon, M., et al. 1997. J. Biol. Chem. 272, 22438.
          Sachs, G., et al. 1995. Ann. Rev. Pharmacol. Toxicol. 35, 277.
          Diaz, D., et al. 1990. Gastroenterology 99, 737.
          Fellenius, E., et al. 1981. Nature 290, 159.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision13-March-2013 JSW
          SynonymsH 168/68, 5-Methoxy-2[(4-methoxy-3,5-dimethyl-2-pyridyl)methylsulfinyl]-1H-benzimidazole
          DescriptionA cell-permeable, selective proton pump inhibitor. Behaves as a prodrug by undergoing an acid-catalyzed rearrangement to a thiol-reactive cationic sulfenamide that inhibits (H+-K+)-ATPase in the gastric milieu. Also acts as an aryl hydrocarbon-like inducer of cytochrome P450 secretion in human liver.
          FormTan to off-white solid
          Intert gas (Yes/No) Packaged under inert gas
          CAS number73590-58-6
          RTECSDD9087000
          Chemical formulaC₁₇H₁₉N₃O₃S
          Structure formulaStructure formula
          Purity≥94% by HPLC
          ContaminantsHeavy metals: ≤20 ppm
          SolubilityDMSO (25 mg/ml)
          Storage +2°C to +8°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Irritant
          Merck USA index14, 6845
          ReferencesLambrecht, N., et al. 2000. J. Biol. Chem. 275, 4041.
          Besancon, M., et al. 1997. J. Biol. Chem. 272, 22438.
          Sachs, G., et al. 1995. Ann. Rev. Pharmacol. Toxicol. 35, 277.
          Diaz, D., et al. 1990. Gastroenterology 99, 737.
          Fellenius, E., et al. 1981. Nature 290, 159.