370681 | OXE-R-Gβγ Coupling Modulator, Gue1654 - Calbiochem

370681
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      Overview

      Replacement Information

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      370681-25MG
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          Glass bottle 25 mg
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          Description
          OverviewA membrane-permeant amidobenzobisthiazolo compound that modulates OXE-R-Gβγ coupling upon receptor stimulation via direct OXE-R interaction, without affecting preexisting OXE-R-Gαβ interaction. Selectively inhibits OXE-R-Gβγ coupling-mediated, but not OXE-R-Gα-mediated, downstream cellular signalings (Effective Conc. 1 to 30 µM), displaying no inhibitory activity against cellular functions mediated by Gα or Gβγ when coupled to other GPCRs. Comparing to Gallein (Cat. No. 371708), Gue1654 does not exert its activity via direct Gβγ interaction.
          Catalogue Number370681
          Brand Family Calbiochem®
          SynonymsN-(7-(Methylsulfanyl)[1,3]thiazolo[4,5-g][1,3]benzothiazol-2-yl)-2,2-diphenylacetamide, 7-(Methylthio)-2-((2,2-diphenylacetyl)amino)benzo[1,2-d:4,3-dʹ]bisthiazole
          References
          ReferencesBlattermann, S., et al. 2012. Nat. Chem. Biol. 8, 631.
          Product Information
          FormTan solid
          Hill FormulaC₂₃H₁₇N₃OS₃
          Chemical formulaC₂₃H₁₇N₃OS₃
          ReversibleY
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Primary Target OXE-R-Gβγ coupling
          Purity≥97% by HPLC
          Physicochemical Information
          Cell permeableY
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage +2°C to +8°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          References

          Reference overview
          Blattermann, S., et al. 2012. Nat. Chem. Biol. 8, 631.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision26-April-2013 JSW
          SynonymsN-(7-(Methylsulfanyl)[1,3]thiazolo[4,5-g][1,3]benzothiazol-2-yl)-2,2-diphenylacetamide, 7-(Methylthio)-2-((2,2-diphenylacetyl)amino)benzo[1,2-d:4,3-dʹ]bisthiazole
          DescriptionA membrane-permeant amidobenzobisthiazolo compound that modulates OXE-R-Gβγ coupling upon receptor stimulation via direct OXE-R interaction, but not preexisting OXE-R-Gαβ interaction. Shown to selectively inhibit OXE-R-Gβγ coupling-mediated, but not OXE-R-Gα-mediated, downstream signalings in HEK293 as well as primary human eosinophils and neutrophils (Effective Conc. 1 to 30 µM), displaying no inhibitory activity against cellular functions mediated by Gα or Gβγ when coupled to other GPCRs, including PGD2 receptor CRTH2 (DP2), IL8 receptors CXCR1/2, muscarinic receptor, and C5a receptor. Comparing to Gallein (Cat. No. 371708), Gue1654 does not exert its activity via direct Gβγ interaction.
          FormTan solid
          Intert gas (Yes/No) Packaged under inert gas
          Chemical formulaC₂₃H₁₇N₃OS₃
          Structure formulaStructure formula
          Purity≥97% by HPLC
          SolubilityDMSO (25 mg/ml)
          Storage +2°C to +8°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
          Toxicity Standard Handling
          ReferencesBlattermann, S., et al. 2012. Nat. Chem. Biol. 8, 631.