491207 Novobiocin, Sodium Salt - CAS 1476-53-5 - Calbiochem

491207
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₃₁H₃₅N₂O₁₁ · Na 1476-53-5

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      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      491207-10GM
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          Glass bottle 10 gm
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          491207-1GM
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              Plastic ampoule 1 gm
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              Description
              OverviewDNA gyrase inhibitor used for the production of positively supercoiled plasma DNA. Inhibits retrovirus RNA-dependent DNA polymerases. Also a potent inhibitor of ADP ribosylation eliminates the wild-type pMG110 plasmid from E. coli.
              Catalogue Number491207
              Brand Family Calbiochem®
              References
              ReferencesMarcu, M.G., et al. 2000. J. Natl. Cancer Inst. 92, 242.
              Luhrmann, A., et al. 1998. Antimicrob. Agents Chemotherp. 42, 1911.
              Hooper, D.C., et al. 1984. Antimicrob. Agents Chemother. 25, 586.
              Lockshon, D., and Morris, D.R. 1983. Nucleic Acid. Res. 11, 2999.
              Sumiyoshi, Y., et al. 1983. J. Gen. Virol. 64, 2329.
              Staudenbauer, W.L. 1975. J. Mol. Biol. 96, 201.
              Product Information
              CAS number1476-53-5
              ATP CompetitiveN
              FormWhite to yellow solid
              Hill FormulaC₃₁H₃₅N₂O₁₁ · Na
              Chemical formulaC₃₁H₃₅N₂O₁₁ · Na
              ReversibleN
              Applications
              ApplicationNovobiocin, Sodium Salt, CAS 1476-53-5, is a DNA gyrase inhibitor used for the production of positively supercoiled plasma DNA. Inhibits retrovirus RNA-dependent DNA polymerases.
              Biological Information
              Primary Targetretrovirus RNA-dependent DNA polymerases
              Purity≥90% by HPLC
              Physicochemical Information
              Cell permeableN
              Dimensions
              Materials Information
              Toxicological Information
              Safety Information according to GHS
              RTECSRD5425000
              Safety Information
              Product Usage Statements
              Storage and Shipping Information
              Ship Code Ambient Temperature Only
              Toxicity Harmful
              Storage +2°C to +8°C
              Protect from Light Protect from light
              Do not freeze Ok to freeze
              Special InstructionsFollowing reconstitution, refrigerate (4°C). Stock solutions are stable for 3 months at 4°C.
              Packaging Information
              Transport Information
              Supplemental Information
              Specifications

              Documentation

              SDS

              Title

              Safety Data Sheet (SDS) 

              Certificates of Analysis

              TitleLot Number
              491207

              References

              Reference overview
              Marcu, M.G., et al. 2000. J. Natl. Cancer Inst. 92, 242.
              Luhrmann, A., et al. 1998. Antimicrob. Agents Chemotherp. 42, 1911.
              Hooper, D.C., et al. 1984. Antimicrob. Agents Chemother. 25, 586.
              Lockshon, D., and Morris, D.R. 1983. Nucleic Acid. Res. 11, 2999.
              Sumiyoshi, Y., et al. 1983. J. Gen. Virol. 64, 2329.
              Staudenbauer, W.L. 1975. J. Mol. Biol. 96, 201.
              Data Sheet

              Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

              Revision22-May-2018 JSW
              DescriptionA DNA gyrase inhibitor that can be used for the production of positively supercoiled plasma DNA. Targets the nucleotide-binding site of gyrase B. Exhibits antibacterial properties. Inhibits retrovirus RNA-dependent DNA polymerases. Inhibits LPS-induced production of pro-inflammatory cytokines. Reported to act as a potent inhibitor of ADP ribosylation. Also inhibits protein synthesis and alters the phosphorylation state of several cytosolic proteins.
              FormWhite to yellow solid
              CAS number1476-53-5
              RTECSRD5425000
              Chemical formulaC₃₁H₃₅N₂O₁₁ · Na
              Purity≥90% by HPLC
              SolubilityH₂O (50 mg/ml)
              Storage +2°C to +8°C
              Protect from light
              Do Not Freeze Ok to freeze
              Special InstructionsFollowing reconstitution, refrigerate (4°C). Stock solutions are stable for 3 months at 4°C.
              Toxicity Harmful
              Merck USA index14, 6722
              ReferencesMarcu, M.G., et al. 2000. J. Natl. Cancer Inst. 92, 242.
              Luhrmann, A., et al. 1998. Antimicrob. Agents Chemotherp. 42, 1911.
              Hooper, D.C., et al. 1984. Antimicrob. Agents Chemother. 25, 586.
              Lockshon, D., and Morris, D.R. 1983. Nucleic Acid. Res. 11, 2999.
              Sumiyoshi, Y., et al. 1983. J. Gen. Virol. 64, 2329.
              Staudenbauer, W.L. 1975. J. Mol. Biol. 96, 201.

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              Categories

              Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Cell Cycle/Cell Division > DNA and RNA Polymerase Inhibitors