490070 Nitric Oxide Synthase, Neuronal Inhibitor I - CAS 357965-99-2 - Calbiochem

490070
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₈H₂₁N₇O₂ · 3TFA · 2H₂O 357965-99-2

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      490070-5MG
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          Plastic ampoule 5 mg
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          Description
          OverviewA cell-permeable, potent and highly selective inhibitor of neuronal nitric oxide synthase (nNOS); (Ki = 120 nM). Displays >2500-fold and 320-fold selectivity over eNOS and iNOS, respectively.
          Catalogue Number490070
          Brand Family Calbiochem®
          Synonyms(4S)-N-(4-Amino-5[aminoethyl]aminopentyl)-Nʹ-nitroguanidine, TFA
          References
          ReferencesHah, J.M., et al. 2001. J. Med. Chem. 44, 2667.
          Product Information
          CAS number357965-99-2
          ATP CompetitiveN
          FormWhite to off-white solid
          FormulationSupplied as a dihydrate.
          Hill FormulaC₈H₂₁N₇O₂ · 3TFA · 2H₂O
          Chemical formulaC₈H₂₁N₇O₂ · 3TFA · 2H₂O
          Hygroscopic Hygroscopic
          ReversibleN
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Primary TargetnNOS
          Primary Target K<sub>i</sub>120 nM against nNOS
          Purity≥95% by HPLC
          Physicochemical Information
          Cell permeableY
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage -20°C
          Protect from Light Protect from light
          Hygroscopic Hygroscopic
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          490070

          References

          Reference overview
          Hah, J.M., et al. 2001. J. Med. Chem. 44, 2667.

          Brochure

          Title
          Ionic Liquids Product Range
          Pathways and Biomarkers of Oxidative Stress (EMD)
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision06-July-2010 JSW
          Synonyms(4S)-N-(4-Amino-5[aminoethyl]aminopentyl)-Nʹ-nitroguanidine, TFA
          DescriptionA cell-permeable, potent, and highly selective inhibitor of neuronal nitric oxide synthase (nNOS) (Ki = 120 nM). Displays >2,500-fold and 192-fold selectivity over eNOS and iNOS, respectively.
          FormWhite to off-white solid
          FormulationSupplied as a dihydrate.
          Intert gas (Yes/No) Packaged under inert gas
          CAS number357965-99-2
          Chemical formulaC₈H₂₁N₇O₂ · 3TFA · 2H₂O
          Structure formulaStructure formula
          Purity≥95% by HPLC
          SolubilityH₂O (1 mg/ml)
          Storage -20°C
          Hygroscopic
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Standard Handling
          ReferencesHah, J.M., et al. 2001. J. Med. Chem. 44, 2667.