481990 Nigericin, Sodium Salt, Streptomyces hygroscopicus - CAS 28643-80-3 - Calbiochem

481990
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₄₀H₆₇O₁₁ . Na 28643-80-3

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      481990-10MG
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          Alu drum 10 mg
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          481990-5MG
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              Alu drum 5 mg
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              Description
              OverviewDisrupts the membrane potential and stimulates ATPase activity in mitochondria. Transports monovalent cations across membranes with the following specificity: K+>Rb+>Cs+>>Na+.
              Catalogue Number481990
              Brand Family Calbiochem®
              SynonymsAntibiotic K178
              References
              ReferencesMoriyama, Y., et al. 1994. J. Biochem. 115, 213.
              Eytan, G.D., et al. 1990. J. Biol. Chem. 265, 12949.
              Alonso, M.A., and Carrasco, L. 1981. FEBS Lett. 127, 112.
              Product Information
              CAS number28643-80-3
              ATP CompetitiveN
              FormLyophilized
              Hill FormulaC₄₀H₆₇O₁₁ . Na
              Chemical formulaC₄₀H₆₇O₁₁ . Na
              ReversibleN
              Structure formula ImageStructure formula Image
              Applications
              ApplicationNigericin, Sodium Salt, Streptomyces hygroscopicus, CAS 28643-80-3, is an antibiotic K+ ionophore that disrupts the membrane potential and stimulates ATPase activity in mitochondria.
              Biological Information
              Primary TargetDisrupts the membrane potential and stimulates ATPase activity in mitochondria.
              Purity≥98% by TLC
              Physicochemical Information
              Cell permeableN
              Dimensions
              Materials Information
              Toxicological Information
              Safety Information according to GHS
              RTECSQT6825000
              Safety Information
              R PhraseR: 23/24/25-36/37/38

              Toxic by inhalation, in contact with skin and if swallowed.
              Irritating to eyes, respiratory system and skin.
              S PhraseS: 22-36/37/39-45

              Do not breathe dust.
              Wear suitable protective clothing, gloves and eye/face protection.
              In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
              Product Usage Statements
              Storage and Shipping Information
              Ship Code Ambient Temperature Only
              Toxicity Toxic
              Hazardous Materials Attention: Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
              Storage +2°C to +8°C
              Do not freeze Ok to freeze
              Special InstructionsFollowing reconstitution, aliquot and freeze. Stock solutions are stable for 1 month at -20°C.
              Packaging Information
              Transport Information
              Supplemental Information
              Specifications

              Documentation

              SDS

              Title

              Safety Data Sheet (SDS) 

              Certificates of Analysis

              TitleLot Number
              481990

              References

              Reference overview
              Moriyama, Y., et al. 1994. J. Biochem. 115, 213.
              Eytan, G.D., et al. 1990. J. Biol. Chem. 265, 12949.
              Alonso, M.A., and Carrasco, L. 1981. FEBS Lett. 127, 112.
              Data Sheet

              Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

              Revision15-May-2008 RFH
              SynonymsAntibiotic K178
              DescriptionA monocarboxylate that catalyzes the electroneutral exchange of an alkali metal for H+ (antiport). Transports monovalent cations across membranes with the following specificities: K+>Rb+>Cs+>>Na+. An antibiotic that kills bacteria by facilitating the diffusion of ions across membranes. Disrupts the membrane potential and stimulates mitochondrial ATPase activity.
              FormLyophilized
              CAS number28643-80-3
              RTECSQT6825000
              Chemical formulaC₄₀H₆₇O₁₁ . Na
              Structure formulaStructure formula
              Purity≥98% by TLC
              SolubilityCHCl₃, ethanol, or ethyl acetate
              Storage +2°C to +8°C
              Do Not Freeze Ok to freeze
              Special InstructionsFollowing reconstitution, aliquot and freeze. Stock solutions are stable for 1 month at -20°C.
              Toxicity Toxic
              Merck USA index14, 6541
              ReferencesMoriyama, Y., et al. 1994. J. Biochem. 115, 213.
              Eytan, G.D., et al. 1990. J. Biol. Chem. 265, 12949.
              Alonso, M.A., and Carrasco, L. 1981. FEBS Lett. 127, 112.