481981 Nifedipine - CAS 21829-25-4 - Calbiochem

481981
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₁₇H₁₈N₂O₆ 21829-25-4

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      481981-250MG
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          Plastic ampoule 250 mg
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          Description
          OverviewRelatively selective blocker of L-type Ca2+ channels. One of the most extensively studied blockers of 1,4-dihydropyridine-type Ca2+ channels, and a pharmacologically-useful vasodilator. Induces apoptosis in human glioblastoma cells.
          Catalogue Number481981
          Brand Family Calbiochem®
          SynonymsL-Type Calcium Channel Blocker III
          References
          ReferencesReid, K., et al. 1997. J. Pharmacol. Exp. Ther. 283, 993.
          Kondo, S., et al. 1995. J. Neurosurg. 82, 469.
          Antkiewicz-Michaluk, L., et al. 1994. Eur. J. Pharmacol. 254, 9.
          Calabresi, P., et al. 1994. J. Neurosci. 14, 4871.
          Akman, M.S., et al. 1993. Endocrinology 132, 1286.
          Cirillo, M., et al. 1993. Circ. Res. 72, 847.
          Young, R.J., et al. 1993. Biochim. Biophys. Acta 1146, 81.
          Janis, R., et al. 1987. Adv. Drug Res. 16, 311.
          Product Information
          CAS number21829-25-4
          ATP CompetitiveN
          FormYellow solid
          Hill FormulaC₁₇H₁₈N₂O₆
          Chemical formulaC₁₇H₁₈N₂O₆
          ReversibleN
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Primary TargetL-type Ca2+ channels
          Purity≥98% by UV
          Physicochemical Information
          Cell permeableN
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          RTECSUS7975000
          Safety Information
          R PhraseR: 22

          Harmful if swallowed.
          S PhraseS: 36-26

          Wear suitable protective clothing.
          In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Harmful & Carcinogenic / Teratogenic
          Storage +15°C to +30°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, refrigerate (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          481981

          References

          Reference overview
          Reid, K., et al. 1997. J. Pharmacol. Exp. Ther. 283, 993.
          Kondo, S., et al. 1995. J. Neurosurg. 82, 469.
          Antkiewicz-Michaluk, L., et al. 1994. Eur. J. Pharmacol. 254, 9.
          Calabresi, P., et al. 1994. J. Neurosci. 14, 4871.
          Akman, M.S., et al. 1993. Endocrinology 132, 1286.
          Cirillo, M., et al. 1993. Circ. Res. 72, 847.
          Young, R.J., et al. 1993. Biochim. Biophys. Acta 1146, 81.
          Janis, R., et al. 1987. Adv. Drug Res. 16, 311.

          Brochure

          Title
          Calcium Metabolism and Related Products Brochure
          Channel Blockers Technical Bulletin
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision15-May-2008 RFH
          SynonymsL-Type Calcium Channel Blocker III
          DescriptionRelatively selective blocker of L-type Ca2+ channels. One of the most extensively studied Ca2+ channel blockers of 1,4-dihydropyridine-type and a pharmacologically useful vasodilator. Induces apoptosis in human glioblastoma cells.
          FormYellow solid
          CAS number21829-25-4
          RTECSUS7975000
          Chemical formulaC₁₇H₁₈N₂O₆
          Structure formulaStructure formula
          Purity≥98% by UV
          SolubilityDMSO or Ethanol
          Storage +15°C to +30°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, refrigerate (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Harmful & Carcinogenic / Teratogenic
          Merck USA index14, 6528
          ReferencesReid, K., et al. 1997. J. Pharmacol. Exp. Ther. 283, 993.
          Kondo, S., et al. 1995. J. Neurosurg. 82, 469.
          Antkiewicz-Michaluk, L., et al. 1994. Eur. J. Pharmacol. 254, 9.
          Calabresi, P., et al. 1994. J. Neurosci. 14, 4871.
          Akman, M.S., et al. 1993. Endocrinology 132, 1286.
          Cirillo, M., et al. 1993. Circ. Res. 72, 847.
          Young, R.J., et al. 1993. Biochim. Biophys. Acta 1146, 81.
          Janis, R., et al. 1987. Adv. Drug Res. 16, 311.