GF032 Neurotrophin 4/5

GF032
10 µg  
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      Overview

      Replacement Information

      Key Specifications Table

      SpeciesSourcePurity
      Human Human NT4/5 expressed in E.coli Greater that 98% by SDS-PAGE and HPLC analysis. Endotoxin level is less than 0.1 ng per mg (1EU/mg) of NT-4.
      Description
      Catalogue NumberGF032
      Brand Family Chemicon®
      Trade Name
      • Chemicon
      DescriptionNeurotrophin 4/5
      OverviewNeurotrophin-4 (NT-4/NT-5) is a potent neurotrophic factor which supports the growth and survivability of nerve and/or glial cells. The active form of human NT-4 is a dimer, formed by two identical 130 amino acid subunits, which is held together by strong hydrophobic interactions.
      Alternate Names
      • NT4/5
      References
      Product Information
      PresentationLyophilized protein with no additives.
      Applications
      ApplicationThe Neurotrophin-4 protein (or NT-4/NT-5 protein) is a potent neurotrophic factor which supports the growth & survivability of nerve and/or glial cells.
      Application NotesConcentration range for most in vitro applications is 0.5 to 100 ng/mL. Responding cells include (partial list): Nerve, glial cells.
      Biological Information
      PurityGreater that 98% by SDS-PAGE and HPLC analysis. Endotoxin level is less than 0.1 ng per mg (1EU/mg) of NT-4.
      SourceHuman NT4/5 expressed in E.coli
      Specific ActivityChemicon's human NT-4 is fully biologically active when compared to standards. The ED(50) as determined by the dose-dependent induction of choline acetyl transferase activity in rat basal forebrain primary septal cultures.
      Entrez Gene Number
      Entrez Gene SummaryThis gene is a member of a family of neurotrophic factors, neurotrophins, that control survival and differentiation of mammalian neurons. The expression of this gene is ubiquitous and less influenced by environmental signals. While knock-outs of other neurotrophins including nerve growth factor, brain-derived neurotrophic factor, and neurotrophin 3 prove lethal during early postnatal development, NTF5-deficient mice only show minor cellular deficits and develop normally to adulthood.
      Gene Symbol
      • NTF5
      • NT-4
      • NTF4
      • Neurotrophin-4
      • NT-5
      • NT5
      • NT-4/5
      • NT4
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: P34130 # Target-derived survival factor for peripheral sensory sympathetic neurons.
      SIZE: 210 amino acids; 22427 Da
      SUBCELLULAR LOCATION: Secreted.
      TISSUE SPECIFICITY: Highest levels in prostate, lower levels in thymus, placenta, and skeletal muscle. Expressed in embryonic and adult tissues.
      SIMILARITY: SwissProt: P34130 ## Belongs to the NGF-beta family.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsThe lyophilized powder, though stable at room temperature, is best stored desiccated below 0°C for up to 12 months after date of receipt. After a quick spin, reconstitute with sterile water to a concentration of 0.1-1.0 mg/mL. This solution can be diluted into other aqueous buffers. Reconstitute NT-4 should be stored in undiluted aliquots at -20°C for up to six months.
      Packaging Information
      Material Size10 µg
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      Neurotrophin 4/5 SDS

      Title

      Safety Data Sheet (SDS) 

      Neurotrophin 4/5 Certificates of Analysis

      TitleLot Number
      RECOMBINANT HUMAN NEUROTROPHIN-42906474
      RECOMBINANT HUMAN NEUROTROPHIN-42972372
      RECOMBINANT HUMAN NEUROTROPHIN-42487589
      RECOMBINANT HUMAN NEUROTROPHIN-42967787
      RECOMBINANT HUMAN NEUROTROPHIN-4 - 22711342271134
      RECOMBINANT HUMAN NEUROTROPHIN-4 -26439792643979
      RECOMBINANT HUMAN NEUROTROPHIN-4 -27165252716525
      RECOMBINANT HUMAN NEUROTROPHIN-4 -27557412755741
      RECOMBINANT HUMAN NEUROTROPHIN-4 -28106302810630
      RECOMBINANT HUMAN NEUROTROPHIN-4 -31601613160161

      Related Products & Applications

      Product Families

      Categories

      Life Science Research > Proteins and Enzymes > Cytokines & Growth Factors
      Life Science Research > Cell Culture and Systems > Cell Culture Media and Supplements > Cell Culture Supplements > Cytokines & Growth Factors