4801 Neomycin Sulfate - CAS 1405-10-3 - Calbiochem

4801
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₂₃H₄₆N₆O₁₃ . 3H₂SO₄ 1405-10-3

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      4801-25GM
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          Plastic ampoule 25 gm
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          Description
          OverviewAn aminoglycoside antibiotic that inhibits translation by binding to the small subunit of prokaryotic ribosomes. Recently shown to inhibit angiogenin-induced angiogenesis. Blocks voltage-sensitive Ca2+ channels without affecting Na+ - Ca2+ antiporter in nerve cells. A potent inhibitor of skeletal muscle sarcoplasmic reticulum Ca2+ release. An inhibitor of inositol phospholipid turnover. A non-specific phospholipase C inhibitor. Also inhibits phosphatidylcholine-phospholipase D activity (IC50 = 65 µM). Inhibits angiogenin-induced angiogenesis in the chicken chorioallantoic membrane (20 ng per egg).
          Catalogue Number4801
          Brand Family Calbiochem®
          References
          ReferencesHu, G.F. 1998. Proc. Natl. Acad. Sci. USA 95, 9791.
          Wang, J.P., et al. 1996. J. Biol. Chem. 271, 8387.
          Smith, M.J., et al. 1995. Dev. Biol. 167, 239.
          Phillippe, M. 1994. Biochem. Biophys. Res. Commun. 205, 245.
          Canzoniero, L.M., et al. 1993. Eur. J. Pharmacol. 245, 97.
          Liscovitch, M., et al. 1991. Biochem. J. 279, 319.
          Product Information
          CAS number1405-10-3
          Activity≥600 IU/mg
          FormWhite solid
          Hill FormulaC₂₃H₄₆N₆O₁₃ . 3H₂SO₄
          Chemical formulaC₂₃H₄₆N₆O₁₃ . 3H₂SO₄
          Structure formula ImageStructure formula Image
          Applications
          ApplicationNeomycin Sulfate, CAS 1405-10-3, is an aminoglycoside antibiotic that inhibits translation by binding to the small subunit of prokaryotic ribosomes.
          Biological Information
          Primary Targetangiogenin-induced angiogenesis
          Primary Target K<sub>i</sub>phosphatidylcholine-phospholipase D activity (IC₅₀ = 65 µM), inhibits angiogenin-induced angiogenesis in the chicken chorioallantoic membrane (20 ng per egg)
          Physicochemical Information
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          RTECSQP4375000
          Safety Information
          R PhraseR: 42/43-60-61

          May cause sensitization by inhalation and skin contact.
          May impair fertility.
          May cause harm to the unborn child.
          S PhraseS: 22-36/37-45

          Do not breathe dust.
          Wear suitable protective clothing and gloves.
          In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Carcinogenic / Teratogenic
          Storage +15°C to +30°C
          Protect from Light Protect from light
          Protect from Moisture Protect from moisture
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, store at room temperature (20°C). Stock solutions are stable for up to 3 months at 20°C.
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          4801

          References

          Reference overview
          Hu, G.F. 1998. Proc. Natl. Acad. Sci. USA 95, 9791.
          Wang, J.P., et al. 1996. J. Biol. Chem. 271, 8387.
          Smith, M.J., et al. 1995. Dev. Biol. 167, 239.
          Phillippe, M. 1994. Biochem. Biophys. Res. Commun. 205, 245.
          Canzoniero, L.M., et al. 1993. Eur. J. Pharmacol. 245, 97.
          Liscovitch, M., et al. 1991. Biochem. J. 279, 319.

          Brochure

          Title
          Calcium Metabolism and Related Products Brochure
          Channel Blockers Technical Bulletin

          Technical Info

          Title
          EMD Millipore Regulated Product Information
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision08-October-2007 JSW
          DescriptionAn aminoglycoside antibiotic that inhibits translation by binding to the small subunit of prokaryotic ribosomes. Recetly shown to inhibit angiogenin-induced angiogenesis. Blocks voltage-sensitive Ca2+ channels without affecting the Na+-Ca2+ antiporter in nerve cells. A potent inhibitor of skeletal muscle sarcoplasmic reticulum Ca2+ release. An inhibitor of inositol phospholipid turnover. A non-specific phosolipase C inhibitor. Also inhibits phophatidylcholine-phospholipase D activity (IC50 = 65 µM).
          FormWhite solid
          CAS number1405-10-3
          RTECSQP4375000
          Chemical formulaC₂₃H₄₆N₆O₁₃ . 3H₂SO₄
          Structure formulaStructure formula
          Activity≥600 IU/mg
          SolubilityH₂O (6 mg/ml)
          Storage +15°C to +30°C
          Protect from moisture
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, store at room temperature (20°C). Stock solutions are stable for up to 3 months at 20°C.
          Toxicity Carcinogenic / Teratogenic
          Merck USA index14, 6454
          ReferencesHu, G.F. 1998. Proc. Natl. Acad. Sci. USA 95, 9791.
          Wang, J.P., et al. 1996. J. Biol. Chem. 271, 8387.
          Smith, M.J., et al. 1995. Dev. Biol. 167, 239.
          Phillippe, M. 1994. Biochem. Biophys. Res. Commun. 205, 245.
          Canzoniero, L.M., et al. 1993. Eur. J. Pharmacol. 245, 97.
          Liscovitch, M., et al. 1991. Biochem. J. 279, 319.

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          Categories

          Life Science Research > Inhibitors and Biochemicals > Biochemicals > Antibiotics > Antimicrobial Agents
          Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Lipid Signaling Inhibitors > Phospholipase Inhibitors