492000 NOX Inhibitor III, VAS2870 - CAS 722456-31-7 - Calbiochem

492000
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₁₈H₁₂N₆OS 722456-31-7

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      492000-10MG
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          Glass bottle 10 mg
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          Description
          OverviewA cell-permeable thiotriazolopyrimidine compound that acts as an effective NADPH oxidase (NOX) inhibitor (IC50 = 10.6 µM against NOX activity in human neutrophil lysates) and is widely used for studying NOX-dependent cellular ROS formations in various cultures, including oxLDL-treated HUVEC (complete inhibition at 5 µM), PDGF-induced primary rat VSMC (vascular smooth muscle cells; complete inhibition at 10 µM), as well as aortic sections from spontaneously hypertensive rats (72% inhibition at 10 µM) ex vivo.
          Catalogue Number492000
          Brand Family Calbiochem®
          Synonyms7-(1,3-Benzoxazol-2-ylsulfanyl)-3-benzyl-3H-[1,2,3]triazolo[4,5-d]pyrimidine, 1,3-Benzoxazol-2-yl-3-benzyl-3H-[1,2,3]triazolo[4,5-d]pyrimidin-7-yl sulfide, NADPH Oxidase Inhibitor III, VAS2870
          References
          ReferencesWind, S., et al. 2010. Hypertension 56, 490.
          Lange, S., et al. 2009. Cardiovasc. Res. 81, 159.
          Stielow, C., et al. 2006. Biochem. Biophys. Res. Commun. 344, 200.
          ten Freyhaus, H., et al. 2006. Cardiovasc. Res. 71, 331.
          Product Information
          CAS number722456-31-7
          FormTan solid
          Hill FormulaC₁₈H₁₂N₆OS
          Chemical formulaC₁₈H₁₂N₆OS
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Purity≥95% by HPLC
          Physicochemical Information
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Shipped with Blue Ice or with Dry Ice
          Toxicity Standard Handling
          Storage +2°C to +8°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          492000

          References

          Reference overview
          Wind, S., et al. 2010. Hypertension 56, 490.
          Lange, S., et al. 2009. Cardiovasc. Res. 81, 159.
          Stielow, C., et al. 2006. Biochem. Biophys. Res. Commun. 344, 200.
          ten Freyhaus, H., et al. 2006. Cardiovasc. Res. 71, 331.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision17-April-2012 JSW
          Synonyms7-(1,3-Benzoxazol-2-ylsulfanyl)-3-benzyl-3H-[1,2,3]triazolo[4,5-d]pyrimidine, 1,3-Benzoxazol-2-yl-3-benzyl-3H-[1,2,3]triazolo[4,5-d]pyrimidin-7-yl sulfide, NADPH Oxidase Inhibitor III, VAS2870
          DescriptionA cell-permeable thiotriazolopyrimidine compound that acts as an effective NADPH oxidase (NOX) inhibitor (IC50 = 10.6 µM against NOX activity in human neutrophil lysates) and is widely used for studying NOX-dependent cellular ROS formations in various cultures, including oxLDL-treated HUVEC (complete inhibition at 5 µM), PDGF-induced primary rat VSMC (vascular smooth muscle cells; complete inhibition at 10 µM), as well as aortic sections from spontaneously hypertensive rats (SHRs) (72% inhibition at 10 µM). Also shown to inhibit PDGF-BB-induced murine EB (embryonid body) vacularization (74% inhibition at 50 µM) and improve ACh-induced vasorelaxation of isolated rat aortic rings from both SHRs and non-hypertensive rats ex vivo (by 41.7 and 34.5%, respectively, at 10 µM).
          FormTan solid
          Intert gas (Yes/No) Packaged under inert gas
          CAS number722456-31-7
          Chemical formulaC₁₈H₁₂N₆OS
          Structure formulaStructure formula
          Purity≥95% by HPLC
          SolubilityDMSO (25 mg/ml)
          Storage +2°C to +8°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
          Toxicity Standard Handling
          ReferencesWind, S., et al. 2010. Hypertension 56, 490.
          Lange, S., et al. 2009. Cardiovasc. Res. 81, 159.
          Stielow, C., et al. 2006. Biochem. Biophys. Res. Commun. 344, 200.
          ten Freyhaus, H., et al. 2006. Cardiovasc. Res. 71, 331.