487955 NOC-12 - CAS 146724-89-2 - Calbiochem

487955
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₆H₁₆N₄O₂ 146724-89-2

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      487955-10MG
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          Plastic ampoule 10 mg
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          Description
          OverviewA nitric oxide (NO) donor similar to NOC-5 (Cat. No. 487950) and NOC-7 (Cat. No. 487952) but with a much longer half-life of NO release. Half-life (t½) in PBS, pH 7.4 is 327 minutes at 22°C. Inhibits the proliferation of arterial smooth muscle cells in a dose-dependent manner. Relatively stable in alkaline solution (pH ≥10.0).
          Catalogue Number487955
          Brand Family Calbiochem®
          SynonymsN-Ethyl-2-(1-ethyl-2-hydroxy-2-nitrosohydrazino)ethanamine
          References
          ReferencesAmbalavanan, N., et al. 1999. Biol. Neonate 76, 291.
          Hrabie, J.A., et al. 1993. J. Org. Chem. 58, 1472.
          Product Information
          CAS number146724-89-2
          ATP CompetitiveN
          FormWhite solid
          Hill FormulaC₆H₁₆N₄O₂
          Chemical formulaC₆H₁₆N₄O₂
          Hygroscopic Hygroscopic
          ReversibleN
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Primary TargetA nitric oxide (NO) donor
          Purity≥90% by HPLC
          Physicochemical Information
          Cell permeableN
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          R PhraseR: 36/37/38

          Irritating to eyes, respiratory system and skin.
          S PhraseS: 26-36

          In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
          Wear suitable protective clothing.
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Irritant
          Storage -20°C
          Protect from Light Protect from light
          Hygroscopic Hygroscopic
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution in alkaline solution, aliquot and freeze (-20°C). Unstable in aqueous solutions; reconstitute in H₂O just prior to use. Alkaline stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          487955

          References

          Reference overview
          Ambalavanan, N., et al. 1999. Biol. Neonate 76, 291.
          Hrabie, J.A., et al. 1993. J. Org. Chem. 58, 1472.

          Brochure

          Title
          Nitric Oxide Donors and Scavengers Technical Bulletin
          Nitric Oxide and Oxidative Stress Brochure
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision13-August-2008 RFH
          SynonymsN-Ethyl-2-(1-ethyl-2-hydroxy-2-nitrosohydrazino)ethanamine
          DescriptionA nitric oxide (NO) donor similar to NOC-5 (Cat. No. 487950) and NOC-7 (Cat. No. 487952) but with a much longer half-life of NO release. Half-life (t½) of NO release is 327 min (PBS, pH 7.4, 22°C). Inhibits the proliferation of arterial smooth muscle cells in a dose-dependent manner. Relatively stable in alkaline solution (pH ≥10.0).
          FormWhite solid
          CAS number146724-89-2
          Chemical formulaC₆H₁₆N₄O₂
          Structure formulaStructure formula
          Purity≥90% by HPLC
          SolubilityH₂O or 0.1 N NaOH (≥ pH 10)
          Storage -20°C
          Hygroscopic
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution in alkaline solution, aliquot and freeze (-20°C). Unstable in aqueous solutions; reconstitute in H₂O just prior to use. Alkaline stock solutions are stable for up to 3 months at -20°C.
          Toxicity Irritant
          ReferencesAmbalavanan, N., et al. 1999. Biol. Neonate 76, 291.
          Hrabie, J.A., et al. 1993. J. Org. Chem. 58, 1472.

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          Categories

          Life Science Research > Inhibitors and Biochemicals > Biochemicals > Nucleotides, Nucleosides, Purines, Pyrimidines and Nucleic Acids > Nitric Oxide Donors/Precursors