454585 NMDA Receptor NR2BCT(1292-1304)-TAT - Calbiochem

454585
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical Formula
      C₁₄₃H₂₅₄N₆₄O₃₂

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      454585-2MG
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          Glass bottle 2 mg
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          Description
          OverviewA 13-mer NMDA receptor 2B (NR2B) subunit carboxy terminal (1292-1304) derived peptide that specifically binds DAPK1 (death-associated protein kinase 1) in a reversible manner and antagonizes the activated DAPK1-NR2B interaction and the potentiation of NMDAR function with no effect on either the catalytic activity of DAPK1 or the NMDA receptor physiology. Blocks Ca2+ influx through extrasynaptic NMDA receptors (at 50 µM) and the blood-brain-barrier permeable version, namely NR2BCT(1292-1304) attached to TAT(47-57) via a spacer (6-aminohexanoic acid) protects cortical neurons from NMDA receptor-mediated insults and reduces brain infarction and improve neurological functions in mice (10 mg/kg, i.v.).
          Catalogue Number454585
          Brand Family Calbiochem®
          SynonymsH-KKNRNKLRRQHSY-Ahx-YGRKKRRQRRR-NH₂, Tat-NR2BCT
          References
          ReferencesTu, W., et al. Cell 140, 222.
          Product Information
          FormWhite powder
          FormulationSupplied as a trifluoroacetate salt
          Hill FormulaC₁₄₃H₂₅₄N₆₄O₃₂
          Chemical formulaC₁₄₃H₂₅₄N₆₄O₃₂
          Hygroscopic Hygroscopic
          Applications
          Biological Information
          Purity≥98% by HPLC
          Physicochemical Information
          Peptide SequenceH₂N-Lys-Lys-Asn-Arg-Asn-Lys-Leu-Arg-Arg-Gln-His-Ser-Tyr-Ahx-Tyr-Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg-CONH₂
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
          Toxicity Standard Handling
          Storage -20°C
          Protect from Light Protect from light
          Hygroscopic Hygroscopic
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          References

          Reference overview
          Tu, W., et al. Cell 140, 222.

          Brochure

          Title
          Pathways and Biomarkers of Glutamatergic Synapse Flyer (EMD)
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision27-July-2012 JSW
          SynonymsH-KKNRNKLRRQHSY-Ahx-YGRKKRRQRRR-NH₂, Tat-NR2BCT
          DescriptionA 13-mer NMDA receptor 2B (NR2B) subunit carboxy terminal (1292-1304) derived peptide that specifically binds DAPK1 (death-associated protein kinase 1) in a reversible manner and antagonizes the activated DAPK1-NR2B interaction and the potentiation of NMDAR function with no effect on either the catalytic activity of DAPK1 or the NMDA receptor physiology. Blocks Ca2+ influx through extrasynaptic NMDA receptors (at 50 µM) and the blood-brain-barrier permeable version, namely NR2BCT(1292-1304) attached to TAT(47-57) via a spacer (6-aminohexanoic acid) protects cortical neurons from NMDA receptor-mediated insults and reduces brain infarction and improve neurological functions in mice (10 mg/kg, i.v.).
          FormWhite powder
          FormulationSupplied as a trifluoroacetate salt
          Intert gas (Yes/No) Packaged under inert gas
          Chemical formulaC₁₄₃H₂₅₄N₆₄O₃₂
          Peptide SequenceH₂N-Lys-Lys-Asn-Arg-Asn-Lys-Leu-Arg-Arg-Gln-His-Ser-Tyr-Ahx-Tyr-Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg-CONH₂
          Purity≥98% by HPLC
          SolubilityH,sub>2O (50 mg/ml)
          Storage -20°C
          Hygroscopic
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Standard Handling
          ReferencesTu, W., et al. Cell 140, 222.