481412 NF-kB Activation Inhibitor IV - CAS 139141-12-1 - Calbiochem

481412
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₁₅H₁₃FO 139141-12-1

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      481412-10MG
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          Plastic ampoule 10 mg
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          Description
          OverviewA cell-permeable trans-stilbene Resveratrol (Cat. No. 554325) analog that exhibits much enhanced anti-inflammatory potency, but no anti-oxidant activity. Suppresses LPS-induced COX-2 mRNA expression in BV-2 cells (~46% inhibition at 150 nM) and Shown to be ~130-fold more potent than Resveratrol in inhibiting TNF-α-stimulated NF-κB reporter activity in 293T cells (IC50 = 150 nM).
          Catalogue Number481412
          Brand Family Calbiochem®
          Synonyms(E)-2-Fluoro-4ʹ-methoxystilbene
          References
          ReferencesHeynekamp, J.J., et al. 2006. J. Med. Chem. 49, 7182.
          Product Information
          CAS number139141-12-1
          ATP CompetitiveN
          FormCrystalline solid
          Hill FormulaC₁₅H₁₃FO
          Chemical formulaC₁₅H₁₃FO
          ReversibleN
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Primary TargetNF-κB Activation
          Primary Target IC<sub>50</sub>150 nM inhibiting TNF-α-stimulated NF-κB reporter activity in 293T cells.
          Purity≥98% by HPLC
          Physicochemical Information
          Cell permeableY
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage +2°C to +8°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          481412

          References

          Reference overview
          Heynekamp, J.J., et al. 2006. J. Med. Chem. 49, 7182.

          Brochure

          Title
          Biologics 33.2
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision26-July-2011 RFH
          Synonyms(E)-2-Fluoro-4ʹ-methoxystilbene
          DescriptionA cell-permeable trans-stilbene Resveratrol (Cat. No. 554325) analog that exhibits much enhanced anti-inflammatory potency, but no anti-oxidant activity. Suppresses LPS-induced COX-2 mRNA expression in BV-2 cells (~46% inhibition at 150 nM) and Shown to be ~130-fold more potent than Resveratrol in inhibiting TNF-α-stimulated NF-κB reporter activity in 293T cells (IC50 = 150 nM).
          FormCrystalline solid
          Intert gas (Yes/No) Packaged under inert gas
          CAS number139141-12-1
          Chemical formulaC₁₅H₁₃FO
          Structure formulaStructure formula
          Purity≥98% by HPLC
          SolubilityDMSO (20 mg/ml)
          Storage +2°C to +8°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
          Toxicity Standard Handling
          ReferencesHeynekamp, J.J., et al. 2006. J. Med. Chem. 49, 7182.