481480 NF-κB SN50, Cell-Permeable Inhibitor Peptide - Calbiochem

481480
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical Formula
      C₁₂₉H₂₃₀N₃₆O₂₉S

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      481480-1MG
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          Plastic ampoule 1 mg
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          481480-500UG
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              Plastic ampoule 500 μg
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              Description
              OverviewContains the nuclear localization sequence (NLS) of the transcription factor NF-κB p50 linked to the hydrophobic region (h-region) of the signal peptide of Kaposi fibroblast growth factor (K-FGF). The N-terminal K-FGF h-region confers cell-permeability, while the NLS (360-369) inhibits translocation of the NF-κB active complex into the nucleus. In murine endothelial LE-II cells induced by LPS, NF-κB nuclear translocation is maximally inhibited at 18 µM.
              Catalogue Number481480
              Brand Family Calbiochem®
              SynonymsAAVALLPAVLLALLAPVQRKRQKLMP, NF-κB Activation Inhibitor VIII
              References
              ReferencesLin, Y.-Z., et al. 1995. J. Biol. Chem. 270, 14255.
              Product Information
              ATP CompetitiveN
              DeclarationSold under license of U.S. Patents 5,807,746 and 6,043,339 for research use only. Licenses for commercial manufacture, commercial use, diagnostics, or therapeutics may be obtained by contacting Vanderbilt University, Nashville, Tennessee.
              FormLyophilized
              FormulationSupplied as a trifluoroacetate salt.
              Hill FormulaC₁₂₉H₂₃₀N₃₆O₂₉S
              Chemical formulaC₁₂₉H₂₃₀N₃₆O₂₉S
              Hygroscopic Hygroscopic
              ReversibleN
              Sold on the basis of peptide contentY
              Applications
              Biological Information
              Primary Targettranslocation of the NF-κB active complex into the nucleus
              Purity≥97% by HPLC
              Physicochemical Information
              Cell permeableY
              Peptide ContentY
              Peptide SequenceH-Ala-Ala-Val-Ala-Leu-Leu-Pro-Ala-Val-Leu-Leu-Ala-Leu-Leu-Ala-Pro-Val-Gln-Arg-Lys-Arg-Gln-Lys-Leu-Met-Pro-OH
              Dimensions
              Materials Information
              Toxicological Information
              Safety Information according to GHS
              Safety Information
              Product Usage Statements
              Storage and Shipping Information
              Ship Code Ambient Temperature Only
              Toxicity Standard Handling
              Storage -20°C
              Hygroscopic Hygroscopic
              Do not freeze Ok to freeze
              Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C. Avoid freeze/thaw cycles of solutions.
              Packaging Information
              Transport Information
              Supplemental Information
              Specifications

              Documentation

              SDS

              Title

              Safety Data Sheet (SDS) 

              Certificates of Analysis

              TitleLot Number
              481480

              References

              Reference overview
              Lin, Y.-Z., et al. 1995. J. Biol. Chem. 270, 14255.

              Brochure

              Title
              Biologics 32.3 PDF ( 927 KB )
              Pathways and Biomarkers of Toll-like Receptor (TLR) Signaling (EMD)

              Citations

              Title
            • Teresa Sanchez Alcaraz, et al. (2004) Involvement of Glutathione as a Mechanism of Indirect Protection against Spontaneous Ex Vivo Apoptosis Associated with Bovine Leukemia Virus. Journal of Virology 78, 6180-6190.
            • Data Sheet

              Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

              Revision03-March-2008 JSW
              SynonymsAAVALLPAVLLALLAPVQRKRQKLMP, NF-κB Activation Inhibitor VIII
              DescriptionContains the nuclear localization sequence (NLS) of the transcription factor NF-κB p50 linked to the hydrophobic region (h-region) of the signal peptide of Kaposi fibroblast growth factor (K-FGF). The peptide N-terminal K-FGF h-region confers cell-permeability, while the NLS (360-369) inhibits translocation of the NF-κB active complex into the nucleus. In murine endothelial LE-II cells induced by LPS, inhibition of NF-κB nuclear translocation is maximally inhibited at 18 µM.
              FormLyophilized
              FormulationSupplied as a trifluoroacetate salt.
              Chemical formulaC₁₂₉H₂₃₀N₃₆O₂₉S
              Peptide SequenceH-Ala-Ala-Val-Ala-Leu-Leu-Pro-Ala-Val-Leu-Leu-Ala-Leu-Leu-Ala-Pro-Val-Gln-Arg-Lys-Arg-Gln-Lys-Leu-Met-Pro-OH
              Purity≥97% by HPLC
              SolubilityH₂O (5 mg/ml)
              Storage -20°C
              Hygroscopic
              Do Not Freeze Ok to freeze
              Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C. Avoid freeze/thaw cycles of solutions.
              Toxicity Standard Handling
              ReferencesLin, Y.-Z., et al. 1995. J. Biol. Chem. 270, 14255.
              Citation
            • Teresa Sanchez Alcaraz, et al. (2004) Involvement of Glutathione as a Mechanism of Indirect Protection against Spontaneous Ex Vivo Apoptosis Associated with Bovine Leukemia Virus. Journal of Virology 78, 6180-6190.