480010 NDSB-256 - CAS 81239-45-4 - Calbiochem

480010
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₁₂H₁₉NO₃S 81239-45-4

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      480010-25GM
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          Plastic ampoule 25 gm
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          480010-5GM
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              Description
              OverviewA non-detergent sulfobetaine. Reported to prevent protein aggregation and facilitate the renaturation of chemically and thermally denatured proteins. Zwitterionic over a wide pH range. Easily removed by dialysis. At 1 M, NDSB-256 will restore 30% of the enzymatic activity of denatured egg white lysozyme; at 800 mM it will restore 16% of the enzymatic activity of denatured β-galactosidase.
              Catalogue Number480010
              Brand Family Calbiochem®
              SynonymsDimethylbenzylammonium Propane Sulfonate
              References
              ReferencesGoldberg, M.E., et al. 1996. Folding & Design 1, 21.
              Product Information
              CAS number81239-45-4
              FormWhite solid
              Hill FormulaC₁₂H₁₉NO₃S
              Chemical formulaC₁₂H₁₉NO₃S
              Hygroscopic Hygroscopic
              Structure formula ImageStructure formula Image
              Applications
              Biological Information
              Purity≥99% by TLC
              Physicochemical Information
              Dimensions
              Materials Information
              Toxicological Information
              Safety Information according to GHS
              Safety Information
              R PhraseR: 36/37/38

              Irritating to eyes, respiratory system and skin.
              S PhraseS: 26-36

              In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
              Wear suitable protective clothing.
              Product Usage Statements
              Storage and Shipping Information
              Ship Code Ambient Temperature Only
              Toxicity Irritant
              Storage +15°C to +30°C
              Hygroscopic Hygroscopic
              Do not freeze Ok to freeze
              Special InstructionsFollowing reconstitution, store at room temperature (15-30°C). Stock solutions are stable for up to 3 months at room temperature.
              Packaging Information
              Transport Information
              Supplemental Information
              Specifications

              Documentation

              SDS

              Title

              Safety Data Sheet (SDS) 

              Certificates of Analysis

              TitleLot Number
              480010

              References

              Reference overview
              Goldberg, M.E., et al. 1996. Folding & Design 1, 21.

              Brochure

              Title
              Biological Detergents Brochure
              Bulk Product Guide
              Detergents Booklet
              Detergents and Buffers Technical Bulletin
              Protein Purification and Detection Tools
              Data Sheet

              Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

              Revision02-April-2012 JSW
              SynonymsDimethylbenzylammonium Propane Sulfonate
              DescriptionA member of the class of nondetergent sulfobetaines. Unlike CHAPS and other zwittergents, NDSBs are nondenaturing even at 1 M concentrations. NDSBs have been used to improve the efficiency of solubilization of membrane proteins, to isolate nuclear proteins, to chromatographically purify halophilic proteins in low ionic strength buffers, and to crystallize proteins. They are zwitterionic over a wide pH range and do not absorb significantly in the near UV range. Reported to prevent protein aggregation and facilitate the renaturation of chemically and thermally denatured proteins. NDSBs can be easily removed by dialysis. At 1 M, NDSB-256 will restore 30% of the enzymatic activity of denatured egg white lysozyme; at 800 mM it will restore 16% of the enzymatic activity of denatured β-galactosidase.
              FormWhite solid
              CAS number81239-45-4
              Chemical formulaC₁₂H₁₉NO₃S
              Structure formulaStructure formula
              Purity≥99% by TLC
              SolubilityH₂O (200 mg/ml)
              Storage +15°C to +30°C
              Hygroscopic
              Do Not Freeze Ok to freeze
              Special InstructionsFollowing reconstitution, store at room temperature (15-30°C). Stock solutions are stable for up to 3 months at room temperature.
              Toxicity Irritant
              ReferencesGoldberg, M.E., et al. 1996. Folding & Design 1, 21.

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              Categories

              Life Science Research > Inhibitors and Biochemicals > Biochemicals > Detergents > Non-Detergent Sulfobetaines