681660 N-WASP-Inhibitor, 187-1 - Calbiochem

681660
Price could not be retrieved
Minimum Quantity needs to be mulitiple of
Upon Order Completion More Information
You Saved ()
 
Request Pricing
Limited AvailabilityLimited Availability
Stocked 
Discontinued
Limited Quantities Available
Available
    Remaining : Will advise
      Remaining : Will advise
      Will advise
      Contact Customer Service
      Contact Customer Service
      View Pricing & Availability

      Overview

      Replacement Information

      Key Specifications Table

      Empirical Formula
      C₉₆H₁₂₂N₁₈O₁₆

      Pricing & Availability

      Catalog Number AvailabilityPackaging Qty/Pack Price Quantity
      681660-1MG
      Retrieving availability...
      Limited AvailabilityLimited Availability
      Stocked 
      Discontinued
      Limited Quantities Available
      Available
        Remaining : Will advise
          Remaining : Will advise
          Will advise
          Contact Customer Service
          Contact Customer Service

          Plastic ampoule 1 mg
          Retrieving price...
          Price could not be retrieved
          Minimum Quantity needs to be mulitiple of
          Upon Order Completion More Information
          You Saved ()
           
          Request Pricing
          Description
          OverviewA 14-amino acid cyclic peptide that potently blocks phosphatidylinositol 4,5-bisphosphate (PIP2)-induced actin assembly in Xenopus egg cytoplasmic extract (IC50 ~ 2 µM). Shown to directly bind to neural Wiskott Aldrich syndrome protein (N-WASP) with high-affinity, and prevent the activation of actin-related protein 2/3 (Arp2/3) complex by inhibiting the interaction between N-WASP and Arp2/3.
          Catalogue Number681660
          Brand Family Calbiochem®
          Synonymscyclo(LKDFDPDFLFDPLQ)₂
          References
          ReferencesPeterson, J.R., et al. 2001. Proc. Natl. Acad. Sci. USA 98, 10624.
          Suetsugu, S., et al. 2001. J. Biol. Chem. 276, 33175.
          Product Information
          ATP CompetitiveN
          FormWhite lyophilized solid
          FormulationSupplied as a trifluoroacetate salt.
          Hill FormulaC₉₆H₁₂₂N₁₈O₁₆
          Chemical formulaC₉₆H₁₂₂N₁₈O₁₆
          Hygroscopic Hygroscopic
          ReversibleN
          Applications
          Biological Information
          Primary TargetNeural Wiskott Aldrich syndrome protein (N-WASP)
          Primary Target IC<sub>50</sub>~ 2 µM blocking phosphatidylinositol 4,5-bisphosphate (PIP2)-induced actin assembly in Xenopus egg cytoplasmic extract
          Purity≥95% by HPLC
          Physicochemical Information
          Cell permeableN
          Peptide Sequencecyclo(LLys-DPhe-DPro-DPhe-LPhe-DPro-LGln)₂
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage -20°C
          Hygroscopic Hygroscopic
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          N-WASP-Inhibitor, 187-1 - Calbiochem SDS

          Title

          Safety Data Sheet (SDS) 

          N-WASP-Inhibitor, 187-1 - Calbiochem Certificates of Analysis

          TitleLot Number
          681660

          References

          Reference overview
          Peterson, J.R., et al. 2001. Proc. Natl. Acad. Sci. USA 98, 10624.
          Suetsugu, S., et al. 2001. J. Biol. Chem. 276, 33175.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision16-September-2008 RFH
          Synonymscyclo(LKDFDPDFLFDPLQ)₂
          DescriptionA 14-amino acid cyclic peptide that potently blocks phosphatidylinositol 4,5-bisphosphate (PIP2)-induced actin assembly in Xenopus egg cytoplasmic extract (IC50 ~2 µM). Shown to directly bind to neural Wiskott Aldrich syndrome protein (N-WASP) with high-affinity, and allosterically stabilize the autoinhibited conformation of N-WASP. It prevents the activation of actin-related protein 2/3 (Arp2/3) complex by blocking the interaction between N-WASP and Arp2/3.
          FormWhite lyophilized solid
          FormulationSupplied as a trifluoroacetate salt.
          Intert gas (Yes/No) Packaged under inert gas
          Chemical formulaC₉₆H₁₂₂N₁₈O₁₆
          Peptide Sequencecyclo(LLys-DPhe-DPro-DPhe-LPhe-DPro-LGln)₂
          Purity≥95% by HPLC
          SolubilityDMSO (1 mg/ml) or Acetic Acid (5%)
          Storage -20°C
          Hygroscopic
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
          Toxicity Standard Handling
          ReferencesPeterson, J.R., et al. 2001. Proc. Natl. Acad. Sci. USA 98, 10624.
          Suetsugu, S., et al. 2001. J. Biol. Chem. 276, 33175.