475981 Myosin Light Chain Kinase Inhibitor Peptide 18 - Calbiochem

475981
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical Formula
      C₆₀H₁₀₅N₂₃O₁₁

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      475981-5MG
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      Limited AvailabilityLimited Availability
      Stocked 
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          Plastic ampoule 5 mg
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          Description
          OverviewA highly basic, cell-permeable, nonapeptide that acts as a selective Myosin Light Chain Kinase (MLCK) inhibitor (IC50 = 50 nM). The inhibition is competitive with respect to the peptide substrate (Ki = 52 nM) and displays a mixed mode of inhibition with respect to ATP. Does not interfere with kinase activation by calmodulin (CaM), nor does it inhibit the activities of CaMKII and PKA.
          Catalogue Number475981
          Brand Family Calbiochem®
          SynonymsMLCK Inhibitor Peptide 18, H-RKKYKYRRK-NH₂, MLCK Inhibitor IV
          References
          ReferencesZolotarevsky, Y., et al. 2002. Gastroenterology 123, 163.
          Lukas, T.J., et al. 1999. J. Med. Chem. 42, 910.
          Product Information
          ATP CompetitiveN
          FormWhite lyophilized solid
          FormulationSupplied as a trifluoroacetate salt.
          Hill FormulaC₆₀H₁₀₅N₂₃O₁₁
          Chemical formulaC₆₀H₁₀₅N₂₃O₁₁
          Hygroscopic Hygroscopic
          ReversibleN
          Applications
          Biological Information
          Primary TargetMlck
          Primary Target IC<sub>50</sub>50 nM against MLCK
          Purity≥97% by HPLC
          Physicochemical Information
          Cell permeableY
          Peptide SequenceH-Arg-Lys-Lys-Tyr-Lys-Tyr-Arg-Arg-Lys-NH₂
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Blue Ice Only
          Toxicity Standard Handling
          Storage -20°C
          Hygroscopic Hygroscopic
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          475981

          References

          Reference overview
          Zolotarevsky, Y., et al. 2002. Gastroenterology 123, 163.
          Lukas, T.J., et al. 1999. J. Med. Chem. 42, 910.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision12-December-2008 JSW
          SynonymsMLCK Inhibitor Peptide 18, H-RKKYKYRRK-NH₂, MLCK Inhibitor IV
          DescriptionA highly basic, cell-permable, nonapeptide that acts as a selective myosin light chain kinase (MLCK) inhibitor (IC50 = 50 nM). Does not block calmodulin (CaM) or inhibit the kinase activities of Ca2+/calmodulin kinase II (CaMKII) or protein kinase A (PKA). Inhibition is competitive with respect to substrate (Ki = 52 nM). Displays mixed mode inhibition with respect to ATP.
          FormWhite lyophilized solid
          FormulationSupplied as a trifluoroacetate salt.
          Intert gas (Yes/No) Packaged under inert gas
          Chemical formulaC₆₀H₁₀₅N₂₃O₁₁
          Peptide SequenceH-Arg-Lys-Lys-Tyr-Lys-Tyr-Arg-Arg-Lys-NH₂
          Purity≥97% by HPLC
          SolubilityDMSO (5 mg/ml) or H₂O (1 mg/ml)
          Storage -20°C
          Hygroscopic
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
          Toxicity Standard Handling
          ReferencesZolotarevsky, Y., et al. 2002. Gastroenterology 123, 163.
          Lukas, T.J., et al. 1999. J. Med. Chem. 42, 910.