533196 Myogenic miRNA Inhibitor, Cpd1 - Calbiochem

533196
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical Formula
      C₃₃H₂₇NO₆

      Pricing & Availability

      Catalog Number AvailabilityPackaging Qty/Pack Price Quantity
      5.33196.0001
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          Glass bottle 10 mg
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          Description
          OverviewA cell-permeable tetrahydroquinolinedione[b]cyclobutene based compound that acts as a specific inhibitor of microRNA (miRNA)-221/222-myoD regulatory pathway. Inhibits the translation of myoD in C2C12 cells without changing the expression level of myoD mRNA, but reduces myoD protein expression levels. Shown to selectively inhibit miR-1 (IC50 = 2.5 µM), miR-133a and miR-206 (IC50 = 5 µM) in C2C12 cells. However, it does not affect the levels of non-myogenic miR-9, miR-25, miR-150, miR-25, and miR-214. Shown to inhibit the differentiation of C2C12 cells as indicated by the down-regulation of muscle creatine kinase, myosin heavy chain, and myoGenin levels in these cells.

          Please note that the molecular weight for this compound is batch-specific due to variable water content. Please refer to the vial label or the certificate of analysis for the batch-specific molecular weight. The molecular weight provided represents the baseline molecular weight without water.
          Catalogue Number533196
          Brand Family Calbiochem®
          Synonymstert-Butyl (5-(8a-methoxy-3,8-dioxo-2-phenyl-2a,3,8,8a-tetrahydrocyclobuta[b]naphthalen-1-yl)quinolin-8-yl) carbonate
          References
          ReferencesTan, S., et al. 2014. Chem. & Biol. 21, 1265.
          Product Information
          FormPale yellow solid
          Hill FormulaC₃₃H₂₇NO₆
          Chemical formulaC₃₃H₂₇NO₆
          Applications
          Biological Information
          Primary TargetmiR-221/22
          Primary Target IC<sub>50</sub>2.5 µ
          Purity≥98% by HPLC
          Physicochemical Information
          Cell permeableY
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
          Toxicity Standard Handling
          Storage -20°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          Myogenic miRNA Inhibitor, Cpd1 - Calbiochem SDS

          Title

          Safety Data Sheet (SDS) 

          References

          Reference overview
          Tan, S., et al. 2014. Chem. & Biol. 21, 1265.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision26-June-2017 JSW
          Synonymstert-Butyl (5-(8a-methoxy-3,8-dioxo-2-phenyl-2a,3,8,8a-tetrahydrocyclobuta[b]naphthalen-1-yl)quinolin-8-yl) carbonate
          DescriptionA cell-permeable tetrahydroquinolinedione[b]cyclobutene based compound that acts as a specific inhibitor of microRNA (miRNA)-221/222-myoD regulatory pathway. Inhibits the translation of myoD in C2C12 cells without changing the expression level of myoD mRNA, but reduces myoD protein expression levels. Shown to selectively inhibit miR-1 (IC50 = 2.5 µM), miR-133a and miR-206 (IC50 = 5 µM) in C2C12 cells. However, it does not affect the levels of non-myogenic miR-9, miR-25, miR-150, miR-25, and miR-214. Shown to inhibit the differentiation of C2C12 cells as indicated by the down-regulation of muscle creatine kinase, myosin heavy chain, and myoGenin levels in these cells.
          FormPale yellow solid
          Intert gas (Yes/No) Packaged under inert gas
          Chemical formulaC₃₃H₂₇NO₆
          Purity≥98% by HPLC
          SolubilityDMSO (50 mg/ml)
          Storage -20°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Standard Handling
          ReferencesTan, S., et al. 2014. Chem. & Biol. 21, 1265.