532280 Myeloperoxidase Inhibitor III, HX1 - Calbiochem

532280
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical Formula
      C₁₄H₁₀F₆N₄O₃

      Pricing & Availability

      Catalog Number AvailabilityPackaging Qty/Pack Price Quantity
      5322800001
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          Glass bottle 10 mg
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          Description
          OverviewA cell-permeable, trifluoromethyl substituted aromatic hydroxamate compound that acts as a highly potent, selective, mixed type, reversible inhibitor of the chlorination activity of myeloperoxidase (MPO; IC50 = 5 nM). Tightly binds within the active site cavity above the heme and blocks the substrate channel. Displays over 300-fold greater selectivity for MPO when tested against a panel of redox enzymes, including lactoperoxidase (IC50 = 6.3 µM) and thyroid peroxidase (IC50 = 1.59 µM). Blocks the production of hypochlorous acid by human neutrophils (IC50 = 50 nM) and inhibits the formation of NADH bromohydrin (IC50 = 70 nM with 50 µM H2O2 and 10 mM NaBr).

          Please note that the molecular weight for this compound is batch-specific due to variable water content.
          Catalogue Number532280
          Brand Family Calbiochem®
          SynonymsMPO Inhibitor III, HX1
          References
          ReferencesForbes, L. V., et al. 2013. J. Bio. Chem. 288, 36636.
          Product Information
          FormWhite powder
          Hill FormulaC₁₄H₁₀F₆N₄O₃
          Chemical formulaC₁₄H₁₀F₆N₄O₃
          ReversibleY
          Applications
          Biological Information
          Primary TargetMPO
          Purity≥98% by HPLC
          Physicochemical Information
          Cell permeableY
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage +2°C to +8°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          Myeloperoxidase Inhibitor III, HX1 - Calbiochem SDS

          Title

          Safety Data Sheet (SDS) 

          References

          Reference overview
          Forbes, L. V., et al. 2013. J. Bio. Chem. 288, 36636.

          Brochure

          Title
          Pathways and Biomarkers of Oxidative Stress (EMD)

          Technical Info

          Title
          White Paper: Further considerations of antibody validation and usage. (EMD)
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision27-January-2015 JSW
          SynonymsMPO Inhibitor III, HX1
          DescriptionA cell-permeable, trifluoromethyl substituted aromatic hydroxamate compound that acts as a highly potent, selective, mixed type, reversible inhibitor of the chlorination activity of myeloperoxidase (MPO; IC50 = 5 nM). Tightly binds within the active site cavity above the heme and blocks the substrate channel. Displays over 300-fold greater selectivity for MPO when tested against a panel of redox enzymes, including lactoperoxidase (IC50 = 6.3 µM) and thyroid peroxidase (IC50 = 1.59 µM). Blocks the production of hypochlorous acid by human neutrophils (IC50 = 50 nM) and inhibits the formation of NADH bromohydrin (IC50 = 70 nM with 50 µM H2O2 and 10 mM NaBr).
          FormWhite powder
          Intert gas (Yes/No) Packaged under inert gas
          Chemical formulaC₁₄H₁₀F₆N₄O₃
          Purity≥98% by HPLC
          SolubilityDMSO (50 mg/ml)
          Storage +2°C to +8°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Standard Handling
          ReferencesForbes, L. V., et al. 2013. J. Bio. Chem. 288, 36636.