475913 Mycophenolic Acid - CAS 24280-93-1 - Calbiochem

475913
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₁₇H₂₀O₆ 24280-93-1

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      475913-100MG
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          Plastic ampoule 100 mg
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          475913-500MG
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              Plastic ampoule 500 mg
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              Description
              OverviewAn immunosuppressive agent that inhibits de novo purine nucleotide synthesis via inhibition of inosine monophosphate dehydrogenase and prevents the formation of XMP and GMP. Useful for selection of animal cells that express the E. coli gene coding for xanthine-guanine phosphoribosyltransferase. Also suppresses cytokine-induced nitric oxide production in mouse and rat vascular endothelial cells.
              Catalogue Number475913
              Brand Family Calbiochem®
              Synonyms6-(4-Hydroxy-6-methoxy-7-methyl-3-oxo-5-phthalanyl)-4-methyl-4-hexenoic Acid, MPA
              References
              ReferencesLangman, L.J., et al. 1995. Clin. Chem. 41, 295.
              Senda, M., et al. 1995. Transplantation 60, 1143.
              Warner-Bartnicki, A.L., et al. 1993. Exp. Cell Res. 204, 241.
              Falkner, F.G., and Moss, B. 1988. J. Virol. 62, 1849.
              Cohen, M.B., et al. 1981. J. Biol. Chem. 256, 8713.
              Mulligan, R.C., and Berg, P. 1981. Proc. Natl. Acad. Sci. USA 78, 2072.
              Product Information
              CAS number24280-93-1
              ATP CompetitiveN
              FormWhite to off-white solid
              Hill FormulaC₁₇H₂₀O₆
              Chemical formulaC₁₇H₂₀O₆
              ReversibleN
              Structure formula ImageStructure formula Image
              Applications
              Biological Information
              Primary TargetInosine monophosphate dehydrogenase
              Purity≥95% by HPLC
              Physicochemical Information
              Cell permeableN
              Dimensions
              Materials Information
              Toxicological Information
              Safety Information according to GHS
              RTECSMP8050000
              Safety Information
              R PhraseR: 20/21/22-40

              Harmful by inhalation, in contact with skin and if swallowed.
              Limited evidence of a carcinogenic effect.
              S PhraseS: 22-36

              Do not breathe dust.
              Wear suitable protective clothing.
              Product Usage Statements
              Storage and Shipping Information
              Ship Code Ambient Temperature Only
              Toxicity Harmful & Carcinogenic / Teratogenic
              Storage +15°C to +30°C
              Do not freeze Ok to freeze
              Special InstructionsFollowing reconstitution, sterilize by filtration through a 0.22 µm pore-size filter, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
              Packaging Information
              Transport Information
              Supplemental Information
              Specifications

              Documentation

              SDS

              Title

              Safety Data Sheet (SDS) 

              Certificates of Analysis

              TitleLot Number
              475913

              References

              Reference overview
              Langman, L.J., et al. 1995. Clin. Chem. 41, 295.
              Senda, M., et al. 1995. Transplantation 60, 1143.
              Warner-Bartnicki, A.L., et al. 1993. Exp. Cell Res. 204, 241.
              Falkner, F.G., and Moss, B. 1988. J. Virol. 62, 1849.
              Cohen, M.B., et al. 1981. J. Biol. Chem. 256, 8713.
              Mulligan, R.C., and Berg, P. 1981. Proc. Natl. Acad. Sci. USA 78, 2072.

              Brochure

              Title
              Antibiotics Profiler
              Nitric Oxide and Oxidative Stress Brochure
              Data Sheet

              Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

              Revision15-May-2008 RFH
              Synonyms6-(4-Hydroxy-6-methoxy-7-methyl-3-oxo-5-phthalanyl)-4-methyl-4-hexenoic Acid, MPA
              DescriptionAn immunosuppressive agent that inhibits de novo purine nucleotide synthesis via inhibition of IMP dehydrogenase and prevents the formation of XMP and GMP. Useful for selection of animal cells that express the E. coli gene coding for xanthine-guanine phosphoribosyltransferase. Also suppresses cytokine-induced nitric oxide production in mouse and rat vascular endothelial cells.
              FormWhite to off-white solid
              CAS number24280-93-1
              RTECSMP8050000
              Chemical formulaC₁₇H₂₀O₆
              Structure formulaStructure formula
              Purity≥95% by HPLC
              SolubilityEthanol or 100 mM NaOH (10 mg/ml)
              Storage +15°C to +30°C
              Do Not Freeze Ok to freeze
              Special InstructionsFollowing reconstitution, sterilize by filtration through a 0.22 µm pore-size filter, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
              Toxicity Harmful & Carcinogenic / Teratogenic
              Merck USA index14 6327
              ReferencesLangman, L.J., et al. 1995. Clin. Chem. 41, 295.
              Senda, M., et al. 1995. Transplantation 60, 1143.
              Warner-Bartnicki, A.L., et al. 1993. Exp. Cell Res. 204, 241.
              Falkner, F.G., and Moss, B. 1988. J. Virol. 62, 1849.
              Cohen, M.B., et al. 1981. J. Biol. Chem. 256, 8713.
              Mulligan, R.C., and Berg, P. 1981. Proc. Natl. Acad. Sci. USA 78, 2072.