475951 MreB Perturbing Compound A22 - CAS 22816-60-0 - Calbiochem

475951
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₈H₈Cl₂N₂S • HCl 22816-60-0

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      475951-25MG
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          Plastic ampoule 25 mg
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          Description
          OverviewA cell-permeable isothiourea compound that specifically, rapidly and reversibly perturbs MreB function without affecting eukaryotic actin polymerization. Reported to affect the growth and morphology of Caulobacter crescentus, convert rod-shaped E. coli to round cells, and block DNA segregation without affecting DNA replication. Suggested to interact with MreB's nucleotide binding pocket and is useful for the temporal analysis of MreB function.
          Catalogue Number475951
          Brand Family Calbiochem®
          SynonymsS-(3,4-Dichlorobenzyl)isothiourea, HCl
          References
          ReferencesGitai, Z., et al. 2005. Cell 120, 329.
          Jensen, R.B., et al. 2002. Nat. Rev. Mol. Cell Biol. 3, 167.
          Iwai, N., et al. 2002. Biosci. Biotechnol. Biochem. 66, 2658.
          Product Information
          CAS number22816-60-0
          ATP CompetitiveN
          FormWhite solid
          Hill FormulaC₈H₈Cl₂N₂S • HCl
          Chemical formulaC₈H₈Cl₂N₂S • HCl
          Hygroscopic Hygroscopic
          ReversibleY
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Primary TargetMreB
          Purity≥95% by HPLC
          Physicochemical Information
          Cell permeableY
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
          Toxicity Standard Handling
          Storage +2°C to +8°C
          Protect from Light Protect from light
          Hygroscopic Hygroscopic
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution in DMSO, aliquot and freeze (-20°C. DMSO stock solutions are stable for up to 1 month at -20°C. Reconstitute in H₂O just prior to use; aqueous stock solutions are stable for up to 12 hr. Stable for up to 2 days in acidic medium.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          475951

          References

          Reference overview
          Gitai, Z., et al. 2005. Cell 120, 329.
          Jensen, R.B., et al. 2002. Nat. Rev. Mol. Cell Biol. 3, 167.
          Iwai, N., et al. 2002. Biosci. Biotechnol. Biochem. 66, 2658.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision11-August-2008 RFH
          SynonymsS-(3,4-Dichlorobenzyl)isothiourea, HCl
          DescriptionA cell-permeable isothiourea compound that specifically, rapidly, and reversibly perturbs MreB function without affecting eukaryotic actin polymerization. Reported to affect the growth and morphology of Caulobacter crescentus, convert rod-shaped E. coli to round cells, and block DNA segregation without affecting DNA replication. Suggested to interact with the nucleotide binding pocket of MreB and is useful for the temporal analysis of MreB function.
          FormWhite solid
          Intert gas (Yes/No) Packaged under inert gas
          CAS number22816-60-0
          Chemical formulaC₈H₈Cl₂N₂S • HCl
          Structure formulaStructure formula
          Purity≥95% by HPLC
          SolubilityDMSO (200 mg/ml) or H₂O (2 mg/ml)
          Storage +2°C to +8°C
          Hygroscopic
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution in DMSO, aliquot and freeze (-20°C. DMSO stock solutions are stable for up to 1 month at -20°C. Reconstitute in H₂O just prior to use; aqueous stock solutions are stable for up to 12 hr. Stable for up to 2 days in acidic medium.
          Toxicity Standard Handling
          ReferencesGitai, Z., et al. 2005. Cell 120, 329.
          Jensen, R.B., et al. 2002. Nat. Rev. Mol. Cell Biol. 3, 167.
          Iwai, N., et al. 2002. Biosci. Biotechnol. Biochem. 66, 2658.