475879 Monastrol - CAS 254753-54-3 - Calbiochem

475879
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₁₄H₁₆N₂O₃S 254753-54-3

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      475879-1MG
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          Plastic ampoule 1 mg
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          475879-5MG
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              Plastic ampoule 5 mg
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              Description
              OverviewA potent, cell-permeable, non-tubulin-interacting mitosis inhibitor. Arrests mammalian cells in mitosis with monopolar spindles. In vitro, it specifically inhibits the motility of the mitotic kinesin Eg5, a motor protein involved in the assembly and maintenance of the mitotic spindle (IC50 = 14 µM).
              Catalogue Number475879
              Brand Family Calbiochem®
              Synonyms4-(3-Hydroxyphenyl)-6-methyl-2-thioxo-1,2,3,4-tetrahydro-4H-pyrimidin-5-carboxylic Acid Ethyl Ester, Eg5 Inhibitor I
              References
              ReferencesKapoor, T.M., et al. 2000. J. Cell Biol. 150, 975.
              Mayer, T.U., et al. 1999. Science 286, 971.
              Product Information
              CAS number254753-54-3
              ATP CompetitiveN
              FormWhite solid
              Hill FormulaC₁₄H₁₆N₂O₃S
              Chemical formulaC₁₄H₁₆N₂O₃S
              ReversibleN
              Structure formula ImageStructure formula Image
              Applications
              Biological Information
              Primary TargetMitotic kinesin Eg5
              Primary Target IC<sub>50</sub>14 µM against mitotic kinesin Eg5
              Purity≥95% by HPLC
              Physicochemical Information
              Cell permeableY
              Dimensions
              Materials Information
              Toxicological Information
              Safety Information according to GHS
              Safety Information
              Product Usage Statements
              Storage and Shipping Information
              Ship Code Ambient Temperature Only
              Toxicity Standard Handling
              Storage -20°C
              Protect from Light Protect from light
              Do not freeze Ok to freeze
              Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
              Packaging Information
              Packaged under inert gas Packaged under inert gas
              Transport Information
              Supplemental Information
              Specifications

              Documentation

              SDS

              Title

              Safety Data Sheet (SDS) 

              Certificates of Analysis

              TitleLot Number
              475879

              References

              Reference overview
              Kapoor, T.M., et al. 2000. J. Cell Biol. 150, 975.
              Mayer, T.U., et al. 1999. Science 286, 971.
              Data Sheet

              Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

              Revision07-April-2008 RFH
              Synonyms4-(3-Hydroxyphenyl)-6-methyl-2-thioxo-1,2,3,4-tetrahydro-4H-pyrimidin-5-carboxylic Acid Ethyl Ester, Eg5 Inhibitor I
              DescriptionA potent, cell-permeable, nontubulin-interacting mitosis inhibitor. Arrests mammalian cells in mitosis with monopolar spindles. In vitro, it specifically inhibits the motility of the mitotic kinesin Eg5, a motor protein involved in the assembly and maintenance of the mitotic spindle (IC50 = 14 µM).
              FormWhite solid
              Intert gas (Yes/No) Packaged under inert gas
              CAS number254753-54-3
              Chemical formulaC₁₄H₁₆N₂O₃S
              Structure formulaStructure formula
              Purity≥95% by HPLC
              SolubilityDMSO (100 mg/ml)
              Storage -20°C
              Protect from light
              Do Not Freeze Ok to freeze
              Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
              Toxicity Standard Handling
              ReferencesKapoor, T.M., et al. 2000. J. Cell Biol. 150, 975.
              Mayer, T.U., et al. 1999. Science 286, 971.