Antibiotic and carcinostatic agent. Inhibits DNA synthesis by cross-linking DNA at guanine and adenine residues; disrupts base pairing. Induces apoptosis in gastric cancer cells.
More>>Antibiotic and carcinostatic agent. Inhibits DNA synthesis by cross-linking DNA at guanine and adenine residues; disrupts base pairing. Induces apoptosis in gastric cancer cells. Less<<
MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
The quantity field is empty. Please enter a quantity of 1 or more to add items to your cart.
Description
Overview
Antibiotic and carcinostatic agent. Inhibits DNA synthesis by cross-linking DNA at guanine and adenine residues; disrupts base pairing. Induces apoptosis in gastric cancer cells. Blocks the cell cycle at the G2 phase. Potency: ≥970 µg/mg.
Catalogue Number
475820
Brand Family
Calbiochem®
Synonyms
Mitocin C, MMC
References
References
Kryt, F.A., et al. 1996. Blood 89, 938. Schwartz, G.K., et al. 1995. J. Natl. Cancer Inst. 87, 1394. Folnan, R.S., 1993. Oncology 50, 24. Tomasz, M., et al. 1987. Science 235, 1204.
Product Information
CAS number
50-07-7
Form
Purple solid
Hill Formula
C₁₅H₁₈N₄O₅
Chemical formula
C₁₅H₁₈N₄O₅
Structure formula Image
Applications
Biological Information
Biological activity
Potency: ≥ 970 μg/mg mitomycin C
Purity
≥95% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
RTECS
CN0700000
Safety Information
R Phrase
R: 28
Very toxic if swallowed.
S Phrase
S: 36/37-45-28
Wear suitable protective clothing and gloves. In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
Product Usage Statements
Storage and Shipping Information
Ship Code
Ambient Temperature Only
Toxicity
Highly Toxic & Carcinogenic / Teratogenic
Hazardous Materials Attention:
Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
Storage
+2°C to +8°C
Protect from Light
Protect from light
Do not freeze
Ok to freeze
Special Instructions
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.
Revision
30-April-2010 JSW
Synonyms
Mitocin C, MMC
Description
Antibiotic and carcinostatic agent. Inhibits DNA synthesis by cross-linking DNA at guanine and adenine residues; disrupts base pairing. Induces apoptosis in gastic cancer cells. Blocks the cell cycle at the G2 phase.
Form
Purple solid
CAS number
50-07-7
RTECS
CN0700000
Chemical formula
C₁₅H₁₈N₄O₅
Structure formula
Purity
≥95% by HPLC
Biological activity
Potency: ≥ 970 μg/mg mitomycin C
Solubility
H₂O (<1 mg/ml) or Methanol (5 mg/ml)
Storage
+2°C to +8°C
Protect from light
Do Not Freeze
Ok to freeze
Special Instructions
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity
Highly Toxic & Carcinogenic / Teratogenic
Merck USA index
14, 6215
References
Kryt, F.A., et al. 1996. Blood 89, 938. Schwartz, G.K., et al. 1995. J. Natl. Cancer Inst. 87, 1394. Folnan, R.S., 1993. Oncology 50, 24. Tomasz, M., et al. 1987. Science 235, 1204.
