47589 Mitomycin C, Streptomyces caespitosus - CAS 50-07-7 - Calbiochem

47589
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₁₅H₁₈N₄O₅ 50-07-7

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      47589-2MG
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          2 mg
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          Description
          OverviewAntibiotic and carcinostatic agent. Inhibits DNA synthesis by cross-linking DNA at guanine and adenine residues; disrupts base pairing. Forms covalent adducts into deoxyguanine and guanine under acidic conditions. Induces apoptosis in gastric cancer cells. Blocks the cell cycle at the G2 phase.
          Catalogue Number47589
          Brand Family Calbiochem®
          SynonymsMitocin C, MMC
          References
          ReferencesKruyt, F.A., et al. 1996. Blood 89, 938.
          Schwartz, G.K., et al. 1995. J. Natl. Cancer Inst. 87, 1394.
          Folnan, R.S. 1993. Oncology 50 (Suppl. 1), 24.
          Kawasaki, S., et al. 1992. Jpn. J. Cancer Res. 83, 899.
          Malkinson, A.M., et al. 1992. Cancer Res. 52, 4752.
          McEvoy, J.L., et al. 1992. J. Bacteriol. 174, 5471.
          Tomasz, M., et al. 1987. Science 235, 1204.
          Product Information
          CAS number50-07-7
          FormBlue-violet solid
          FormulationProvided as 2 mg antibiotic and 48 mg NaCl.
          Hill FormulaC₁₅H₁₈N₄O₅
          Chemical formulaC₁₅H₁₈N₄O₅
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Purity≥95% by HPLC
          Physicochemical Information
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          RTECSCN0700000
          Safety Information
          R PhraseR: 28

          Very toxic if swallowed.
          S PhraseS: 36/37-45-28

          Wear suitable protective clothing and gloves.
          In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Highly Toxic & Carcinogenic / Teratogenic
          Hazardous Materials Attention: Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
          Storage +2°C to +8°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, store in the refrigerator (4°C) for short-term storage and in a freezer (-20°C) for longer term. Stock solutions are stable for up to 2 weeks at 4°C and up to 3 months at -20°C.
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          47589

          References

          Reference overview
          Kruyt, F.A., et al. 1996. Blood 89, 938.
          Schwartz, G.K., et al. 1995. J. Natl. Cancer Inst. 87, 1394.
          Folnan, R.S. 1993. Oncology 50 (Suppl. 1), 24.
          Kawasaki, S., et al. 1992. Jpn. J. Cancer Res. 83, 899.
          Malkinson, A.M., et al. 1992. Cancer Res. 52, 4752.
          McEvoy, J.L., et al. 1992. J. Bacteriol. 174, 5471.
          Tomasz, M., et al. 1987. Science 235, 1204.

          Brochure

          Title
          Antibiotics Profiler
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision15-May-2008 RFH
          SynonymsMitocin C, MMC
          DescriptionAntibiotic and carcinostatic agent. Inhibits DNA synthesis by cross-linking DNA at guanine and adenine residues, disrupting base pairing. Induces apoptosis in gastic cancer cells. Blocks the cell cycle at the G2 phase.
          FormBlue-violet solid
          FormulationProvided as 2 mg antibiotic and 48 mg NaCl.
          CAS number50-07-7
          RTECSCN0700000
          Chemical formulaC₁₅H₁₈N₄O₅
          Structure formulaStructure formula
          Purity≥95% by HPLC
          SolubilityH₂O (1 mg/ml)
          Storage +2°C to +8°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, store in the refrigerator (4°C) for short-term storage and in a freezer (-20°C) for longer term. Stock solutions are stable for up to 2 weeks at 4°C and up to 3 months at -20°C.
          Toxicity Highly Toxic & Carcinogenic / Teratogenic
          Merck USA index14, 6215
          ReferencesKruyt, F.A., et al. 1996. Blood 89, 938.
          Schwartz, G.K., et al. 1995. J. Natl. Cancer Inst. 87, 1394.
          Folnan, R.S. 1993. Oncology 50 (Suppl. 1), 24.
          Kawasaki, S., et al. 1992. Jpn. J. Cancer Res. 83, 899.
          Malkinson, A.M., et al. 1992. Cancer Res. 52, 4752.
          McEvoy, J.L., et al. 1992. J. Bacteriol. 174, 5471.
          Tomasz, M., et al. 1987. Science 235, 1204.