475843 Minocycline, Hydrochloride - CAS 13614-98-7 - Calbiochem

475843
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₂₃H₂₇N₃O₇ · HCl 13614-98-7

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      475843-50MG
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          Glass bottle 50 mg
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          Description
          Overview

          This product has been discontinued.



          Semi-synthetic tetracycline derivative effective against tetracycline-resistant staphylococci. A matrix metalloproteinase (MMP) inhibitor shown to inhibit tumor-induced angiogenesis. Inhibits stromelysin (MMP-3; IC50 = 290 µM) but does not inhibit other MMPs such as fibroblast collagenase or gelatinase. Potently inhibits PARP-1 (Ki = 13.4 nM) in a NAD+ - competitive manner. Exhibits anti-inflammatory effects and suppresses T cell proliferation.

          Catalogue Number475843
          Brand Family Calbiochem®
          Synonyms7-Dimethylamino-6-demethyl-6-deoxytetracycline, HCl
          References
          ReferencesConrad, C.A., et al. 2006. Proc. Natl. Acad, Sci. USA 103, 9685.
          Gilbertson-Breading, S., et al. 1995. Cancer Chemother. Pharmacol. 36, 418.
          Kloppenburg, M., et al. 1995. Clin. Exp. Immunol. 102, 635.
          Preus, H.R., et al. 1995. J. Clin. Periodontol. 22, 380.
          Weingart, J.D., et al. 1995. J. Neurosurg. 82, 635.
          Tamargo, R.J., et al. 1991. Cancer Res. 51, 672.
          Product Information
          CAS number13614-98-7
          ATP CompetitiveN
          FormDark yellow solid
          Hill FormulaC₂₃H₂₇N₃O₇ · HCl
          Chemical formulaC₂₃H₂₇N₃O₇ · HCl
          ReversibleN
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Primary TargetMetalloproteinase (MMP)
          Primary Target IC<sub>50</sub>290 µM against MMP-3
          Primary Target K<sub>i</sub>13.4 nM against PARP-1
          Purity≥98% by TLC
          Physicochemical Information
          Cell permeableN
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          RTECSQI7630500
          Safety Information
          R PhraseR: 33-36/37/38-63-64

          Danger of cumulative effects.
          Irritating to eyes, respiratory system and skin.
          Possible risk of harm to the unborn child.
          May cause harm to breastfed babies.
          S PhraseS: 22-45-36

          Do not breathe dust.
          In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
          Wear suitable protective clothing.
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Carcinogenic / Teratogenic
          Storage +2°C to +8°C
          Do not freeze Ok to freeze
          Special InstructionsUnstable in solution; reconstitute just prior to use.
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          475843

          References

          Reference overview
          Conrad, C.A., et al. 2006. Proc. Natl. Acad, Sci. USA 103, 9685.
          Gilbertson-Breading, S., et al. 1995. Cancer Chemother. Pharmacol. 36, 418.
          Kloppenburg, M., et al. 1995. Clin. Exp. Immunol. 102, 635.
          Preus, H.R., et al. 1995. J. Clin. Periodontol. 22, 380.
          Weingart, J.D., et al. 1995. J. Neurosurg. 82, 635.
          Tamargo, R.J., et al. 1991. Cancer Res. 51, 672.

          Brochure

          Title
          Antibiotics Profiler
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision15-May-2008 RFH
          Synonyms7-Dimethylamino-6-demethyl-6-deoxytetracycline, HCl
          DescriptionSemi-synthetic tetracycline derivative effective against tetracycline-resistant staphylococci. A matrix metalloproteinase (MMP) inhibitor shown to inhibit tumor-induced angiogenesis. Inhibits stromelysin (MMP-3; IC50 = 290 µM) but does not inhibit other MMPs such as fibroblast collagenase or gelatinase. Potently inhibits PARP-1 (Ki = 13.4 nM) in a NAD+ - competitive manner. Exhibits anti-inflammatory effects and suppresses T cell proliferation.
          FormDark yellow solid
          CAS number13614-98-7
          RTECSQI7630500
          Chemical formulaC₂₃H₂₇N₃O₇ · HCl
          Structure formulaStructure formula
          Purity≥98% by TLC
          SolubilityH₂O (50 mg/ml)
          Storage +2°C to +8°C
          Do Not Freeze Ok to freeze
          Special InstructionsUnstable in solution; reconstitute just prior to use.
          Toxicity Carcinogenic / Teratogenic
          Merck USA index14, 6202
          ReferencesConrad, C.A., et al. 2006. Proc. Natl. Acad, Sci. USA 103, 9685.
          Gilbertson-Breading, S., et al. 1995. Cancer Chemother. Pharmacol. 36, 418.
          Kloppenburg, M., et al. 1995. Clin. Exp. Immunol. 102, 635.
          Preus, H.R., et al. 1995. J. Clin. Periodontol. 22, 380.
          Weingart, J.D., et al. 1995. J. Neurosurg. 82, 635.
          Tamargo, R.J., et al. 1991. Cancer Res. 51, 672.