FCMAB282F | Milli-Mark™ Anti-Integrin αVβ3 Antibody, clone LM609-FITC

FCMAB282F
100 tests  
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      Overview

      Replacement Information

      Key Specifications Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H FC M FITC Monoclonal Antibody
      Description
      Catalogue NumberFCMAB282F
      Trade Name
      • Milli-Mark
      DescriptionMilli-Mark™ Anti-Integrin αVβ3 Antibody, clone LM609-FITC
      Alternate Names
      • Vitronectin Receptor
      • CD51/CD61
      • integrin alphaVbeta3
      • alphaVbeta3
      Background InformationThe integrin family of cell adhesion receptors consists of at least 16 membrane-associated heterodimers, composed of an alpha and beta subunit that associate in a non-covalent manner. The structure and functional diversity of the integrin family are based upon the pairing abilities of the individual alpha and beta subunits. Key to these molecular interactions between the integrin receptors and their respective ligands is the recognition of the Arg-Gly-Asp (RGD) sequence, known to be present in the extracellular matrix components fibronectin, vitronectin, collagen, fibrinogen, and von Willebrand factor (Cheresh, 1991). The involvement of integrins in vascular proliferation, adhesion, and wound repair has been well documented. The adhesion receptor, integrin alphaVbeta3, appears to be selectively expressed on growing blood vessels and has been identified as a marker of angiogenic vascular tissue (Brooks, 1994). Due to its involvement in angiogenesis, integrin alphaVbeta3 is one of the most intensely studied of the integrin receptors.
      References
      Product Information
      FormatFITC
      Control
      • U937 cells
      PresentationPurified mouse monoclonal IgG1 conjugated to FITC in PBS with 0.1% sodium azide and 15 mg/mL BSA.
      Applications
      ApplicationDetect Integrin αVβ3 using this Milli-Mark Anti-Integrin αVβ3 Antibody, clone LM609-FITC validated for use in FC.
      Key Applications
      • Flow Cytometry
      Biological Information
      ImmunogenPurified adhesion receptor from the human melanoma cell line M21 (Cherish, D. and Spiro, R. (1987) J. Biol. Chemistry, 262(36):17703-17711).
      CloneLM609
      HostMouse
      SpecificityAntibody recognizes Integrin αVβ3.
      IsotypeIgG1
      Species Reactivity
      • Human
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • ITGAV
      • DKFZp686A08142
      • MSK8
      • CD51
      • VNRA
      Purification MethodProtein A Purfied
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: P06756 # The alpha-V integrins are receptors for vitronectin, cytotactin, fibronectin, fibrinogen, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin and von Willebrand factor. They recognize the sequence R-G-D in a wide array of ligands. In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions.

      SIZE: 1048 amino acids; 116038 Da

      SUBUNIT: Heterodimer of an alpha and a beta subunit. The alpha subunit is composed of an heavy and a light chain linked by a disulfide bond. Alpha-V associates with either beta-1, beta-3, beta-5, beta-6 or beta-8 subunit. Interacts with HIV-1 Tat.

      SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.

      SIMILARITY: SwissProt: P06756 ## Belongs to the integrin alpha chain family. & Contains 7 FG-GAP repeats.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by flow cytometry using U937 cells.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsFlow Cytometry
      Antibody dilution for cellular staining:

      • Prepare an antibody working solution by diluting the primary antibody 1:5 with PBS
      • Dispense the volume per test of working of solution according to the number of cells indicated in the table below.
      • 5 µL for Guava Flow Cytometer
      • 10 µL for other Flow Cytometry instruments
      Packaging Information
      Material Size100 tests
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      SDS

      Title

      Safety Data Sheet (SDS) 

      Certificates of Analysis

      TitleLot Number
      Milli-Mark Anti-Integrin #945;V#946;3-FITC, clone LM609 - 2161157 2161157
      Milli-Mark Anti-Integrin V3-FITC, clone LM609 - 1951937 1951937
      Milli-Mark Anti-Integrin V3-FITC, clone LM609 - 2032727 2032727
      Milli-Mark Anti-Integrin V3-FITC, clone LM609 - 2073083 2073083
      Milli-Mark Anti-Integrin V3-FITC, clone LM609 - NG1932865 NG1932865
      Milli-Mark Anti-Integrin V3-FITC, clone LM609 - NG1944975 NG1944975
      Milli-Mark Anti-Integrin V3-FITC, clone LM609 - NRG1859106 NRG1859106
      Milli-Mark™ Anti-Integrin αVβ3-FITC, clone LM609 -2509127 2509127
      Milli-Mark™ Anti-Integrin αVβ3-FITC, clone LM609 -2603418 2603418
      Milli-Mark™ Anti-Integrin αVβ3-FITC, clone LM609 -2603862 2603862

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      Categories

      Life Science Research > Antibodies and Assays > Primary Antibodies