448101 Met Kinase Inhibitor - CAS 658084-23-2 - Calbiochem

448101
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₂₈H₃₀ClN₅O₄S 658084-23-2

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      448101-1MG
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          Plastic ampoule 1 mg
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          Description
          OverviewA cell-permeable pyrrole indolinone compound that acts as a potent, reversible, and ATP-competitive inhibitor of Met kinase activity (IC50 = 20 nM). Exhibits > 60-fold selectivity over Flk and > 400-fold selectivity over Ron, FGFR-1, c-Src, Cdk2, PDGFRβ, EGFR, and Tie-2. Shown to inhibit HGF/SF-stimulated cellular signaling and Met-mediated tumorigenesis in various cancer cell lines.
          Catalogue Number448101
          Brand Family Calbiochem®
          Synonyms(3Z)-N-(3-Chlorophenyl)-3-((3,5-dimethyl-4-((4-methylpiperazin-1-yl)carbonyl)-1H-pyrrol-2-yl)methylene)-N-methyl-2-oxo-2,3-dihydro-1H-indole-5-sulfonamide, SU11274
          References
          ReferencesMa. P. C., et al. 2005. Cancer Res. 65, 1479.
          Berthou, S., et al. 2004. Oncogene 23, 5387.
          Wang, X., et al. 2003. Mol. Cancer Ther. 2, 1085.
          Sattler, M., et al. 2003. Cancer Res. 63, 5462.
          Product Information
          CAS number658084-23-2
          ATP CompetitiveY
          FormOrange solid or powder
          Hill FormulaC₂₈H₃₀ClN₅O₄S
          Chemical formulaC₂₈H₃₀ClN₅O₄S
          ReversibleY
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Primary Targetmet kinase activity
          Primary Target IC<sub>50</sub>20 nM against Met kinase activity
          Purity≥98% by HPLC
          Physicochemical Information
          Cell permeableY
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Irritant
          Storage +2°C to +8°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          448101

          References

          Reference overview
          Ma. P. C., et al. 2005. Cancer Res. 65, 1479.
          Berthou, S., et al. 2004. Oncogene 23, 5387.
          Wang, X., et al. 2003. Mol. Cancer Ther. 2, 1085.
          Sattler, M., et al. 2003. Cancer Res. 63, 5462.

          Brochure

          Title
          Biologics 32.4 ( 1.19 MB )
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision07-May-2018 JSW
          Synonyms(3Z)-N-(3-Chlorophenyl)-3-((3,5-dimethyl-4-((4-methylpiperazin-1-yl)carbonyl)-1H-pyrrol-2-yl)methylene)-N-methyl-2-oxo-2,3-dihydro-1H-indole-5-sulfonamide, SU11274
          DescriptionA cell-permeable pyrrole indolinone compound that acts as a potent, reversible, and ATP-competitive inhibitor of Met kinase activity (IC50 = 20 nM). Exhibits >60-fold selectivity over Flk and >400-fold selectivity over Ron, FGFR-1, c-Src, Cdk2, PDGFRβ, EGFR, and Tie-2. Shown to inhibit HGF/SF-stimulated cellular signaling and Met-mediated tumorigenesis in various cancer cell lines.
          FormOrange solid or powder
          Intert gas (Yes/No) Packaged under inert gas
          CAS number658084-23-2
          Chemical formulaC₂₈H₃₀ClN₅O₄S
          Structure formulaStructure formula
          Purity≥98% by HPLC
          SolubilityDMSO (1 mg/ml). Warm as needed for complete solubilization.
          Storage +2°C to +8°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Irritant
          ReferencesMa. P. C., et al. 2005. Cancer Res. 65, 1479.
          Berthou, S., et al. 2004. Oncogene 23, 5387.
          Wang, X., et al. 2003. Mol. Cancer Ther. 2, 1085.
          Sattler, M., et al. 2003. Cancer Res. 63, 5462.