445820 Meriolin 2 - Calbiochem

445820
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical Formula
      C₁₁H₉N₅O

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      445820-5MG
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      Limited AvailabilityLimited Availability
      Stocked 
      Discontinued
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      Available
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          Plastic ampoule 5 mg
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          Description
          OverviewA cell-permeable, ATP-binding site-targeting azaindolopyrimidine compound that inhibits against Cdk2/A, Cdk9/T, DYRK1A, Cdk5/p25, CK1δ/ε, Cdk1/B, and GSK-3α/β kinase activity (IC50 = 18, 18, 35, 50, 50, 57, and 500 nM, respectively). Shown to induce DEVDase activity in SH-SY5Y neuroblastoma cultures (by 5.46-fold in 24 h at 1 µM) and exhibit antiproliferative activity toward SH-SY5Y, multiple myeloma KMS-11, human embryonic kidney HEK293, colorectal adenocarcinoma LS 174T, and glioma GBM cells in vitro (IC50 = 0.41, 0.6, 0.96, 1.06, and 1.21 µM, respectively).
          Catalogue Number445820
          Brand Family Calbiochem®
          Synonyms3-((2-Amino)pyrimidin-4-yl)-4-hydroxy-1H-pyrrolo[2,3-b]pyridine
          References
          ReferencesEchalier, A., et al. 2008. J. Med. Chem. 51, 737.
          Bettayeb, K., et al. 2007. Cancer Res. 67, 8325.
          Product Information
          FormYellow solid
          Hill FormulaC₁₁H₉N₅O
          Chemical formulaC₁₁H₉N₅O
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Purity≥93% by HPLC
          Physicochemical Information
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Regulatory Review
          Storage +2°C to +8°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          445820

          References

          Reference overview
          Echalier, A., et al. 2008. J. Med. Chem. 51, 737.
          Bettayeb, K., et al. 2007. Cancer Res. 67, 8325.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision07-March-2011 RFH
          Synonyms3-((2-Amino)pyrimidin-4-yl)-4-hydroxy-1H-pyrrolo[2,3-b]pyridine
          DescriptionA cell-permeable, ATP-binding site-targeting azaindolopyrimidine compound that inhibits against Cdk2/A, Cdk9/T, DYRK1A, Cdk5/p25, CK1δ/ε, Cdk1/B, and GSK-3α/β kinase activity (IC50 = 18, 18, 35, 50, 50, 57, and 500 nM, respectively). Shown to induce DEVDase activity in SH-SY5Y neuroblastoma cultures (by 5.46-fold in 24 h at 1 µM) and exhibit antiproliferative activity toward SH-SY5Y, multiple myeloma KMS-11, human embryonic kidney HEK293, colorectal adenocarcinoma LS 174T, and glioma GBM cells in vitro (IC50 = 0.41, 0.6, 0.96, 1.06, and 1.21 µM, respectively).
          FormYellow solid
          Intert gas (Yes/No) Packaged under inert gas
          Chemical formulaC₁₁H₉N₅O
          Structure formulaStructure formula
          Purity≥93% by HPLC
          SolubilityDMSO (50 mg/ml)
          Storage +2°C to +8°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Regulatory Review
          ReferencesEchalier, A., et al. 2008. J. Med. Chem. 51, 737.
          Bettayeb, K., et al. 2007. Cancer Res. 67, 8325.