444898 Mastoparan - CAS 72093-21-1 - Calbiochem

444898
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₇₀H₁₃₁N₁₉O₁₅ 72093-21-1

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      444898-1MG
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          Plastic ampoule 1 mg
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          Description
          OverviewA cell-permeable synthetic peptide with sequence identical to Vespula lewisii. Amphiphilic wasp venom tetradecapeptide capable of directly activating pertussis toxin-sensitive G-proteins by a mechanism analogous to that of G-protein-coupled receptors. Acts preferentially on Gi and Go rather than Gs. Potent facilitator of the mitochondrial permeability transition pore that is reported to induce apoptosis in cultured cerebellar granule neurons by causing a dramatic increase in intracellular Ca2+. Acts as a calmodulin antagonist and activates phospholipase A2. Causes a transient Ca2+ release from the sarcoplasmic reticulum. Also reported to inhibit Na+,K+-ATPase activity (IC50 = 7.5 µM).
          Catalogue Number444898
          Brand Family Calbiochem®
          SynonymsINLKALAALAKKIL
          References
          ReferencesHirata, Y., et al. 2000. Mol. Pharmacol. 57, 1235.
          Liz, S.Z., et al. 1997. Brain Res. 771, 184.
          Klinker, J.F., et al. 1996. Biochem. Pharmacol. 51, 217.
          Langel, U., et al. 1996. Regul. Peptides 62, 47.
          Pfeiffer, D.R., et al. 1995. J. Biol. Chem. 270, 4923.
          Igarashi, M., et al. 1993. Science 259, 77.
          Komatsu, M., et al. 1992. Endocrinology 130, 221.
          Adolfo Garcia-Sainz, J., et al. 1991. Biochem. Biophys. Res. Commun. 179, 852.
          Gil, J., et al. 1991. J. Cell Biol. 113, 943.
          Product Information
          CAS number72093-21-1
          ATP CompetitiveN
          FormWhite solid
          FormulationSupplied as a trifluoroacetate salt.
          Hill FormulaC₇₀H₁₃₁N₁₉O₁₅
          Chemical formulaC₇₀H₁₃₁N₁₉O₁₅
          ReversibleN
          Sold on the basis of peptide contentY
          Applications
          Biological Information
          Primary TargetNa+,K+-ATPase activity
          Primary Target IC<sub>50</sub>7.5 µM
          Purity≥97% by HPLC
          Physicochemical Information
          Cell permeableY
          Peptide ContentY
          Peptide SequenceH-Ile-Asn-Leu-Lys-Ala-Leu-Ala-Ala-Leu-Ala-Lys-Lys-Ile-Leu-NH₂
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage -20°C
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          444898

          References

          Reference overview
          Hirata, Y., et al. 2000. Mol. Pharmacol. 57, 1235.
          Liz, S.Z., et al. 1997. Brain Res. 771, 184.
          Klinker, J.F., et al. 1996. Biochem. Pharmacol. 51, 217.
          Langel, U., et al. 1996. Regul. Peptides 62, 47.
          Pfeiffer, D.R., et al. 1995. J. Biol. Chem. 270, 4923.
          Igarashi, M., et al. 1993. Science 259, 77.
          Komatsu, M., et al. 1992. Endocrinology 130, 221.
          Adolfo Garcia-Sainz, J., et al. 1991. Biochem. Biophys. Res. Commun. 179, 852.
          Gil, J., et al. 1991. J. Cell Biol. 113, 943.

          Brochure

          Title
          Calmodulin and Related Products Technical Bulletin
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision04-October-2015 JSW
          SynonymsINLKALAALAKKIL
          DescriptionA cell-permeable synthetic peptide with a sequence identical to Vespula lewisii. Amphiphilic wasp venom tetradecapeptide capable of directly activating pertussis toxin-sensitive G-proteins by a mechanism analogous to that of G-protein-coupled receptors. Acts preferentially on Gi and Go rather than Gs. Potent factor in mitochondrial permeability transition pore. Inhibits calmodulin and activates phospholipase A2. Causes a transient Ca2+ release from the sarcoplasmic reticulum.
          FormWhite solid
          FormulationSupplied as a trifluoroacetate salt.
          CAS number72093-21-1
          Chemical formulaC₇₀H₁₃₁N₁₉O₁₅
          Peptide SequenceH-Ile-Asn-Leu-Lys-Ala-Leu-Ala-Ala-Leu-Ala-Lys-Lys-Ile-Leu-NH₂
          Purity≥97% by HPLC
          SolubilityH₂O (5 mg/ml)
          Storage -20°C
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
          Toxicity Standard Handling
          ReferencesHirata, Y., et al. 2000. Mol. Pharmacol. 57, 1235.
          Liz, S.Z., et al. 1997. Brain Res. 771, 184.
          Klinker, J.F., et al. 1996. Biochem. Pharmacol. 51, 217.
          Langel, U., et al. 1996. Regul. Peptides 62, 47.
          Pfeiffer, D.R., et al. 1995. J. Biol. Chem. 270, 4923.
          Igarashi, M., et al. 1993. Science 259, 77.
          Komatsu, M., et al. 1992. Endocrinology 130, 221.
          Adolfo Garcia-Sainz, J., et al. 1991. Biochem. Biophys. Res. Commun. 179, 852.
          Gil, J., et al. 1991. J. Cell Biol. 113, 943.