504635 MPEP Hydrochloride - CAS 96206-92-7 - Calbiochem

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 6-Methyl-2-(phenylethynyl)pyridine hydrochloride

Primary Target: mGlu₅ receptors
504635
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₁₄H₁₁N Å• HCl 96206-92-7

      Pricing & Availability

      Catalog Number AvailabilityPackaging Qty/Pack Price Quantity
      5.04635.0001
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          		 Glass bottle 10 mg
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          Description
          OverviewA non-competitive, highly potent antagonist selective for mGlu5 receptors (IC50 = 36 nM). Also a positive allosteric modulator of mGlu4and weak anatagonist of NMDA receptors. Biologically active admitted systematically. Widely used in assessing the functional roles of mGlu5 receptors in a variety of research areas, such as learning and memory, sleep, neuroprotection, depression, addiction, anxiety and stress related disorders, analgesia, locomotion, neural plasticity, and Parkinson's disease.
          Catalogue Number504635
          Brand Family Calbiochem®
          Synonyms6-Methyl-2-(phenylethynyl)pyridine hydrochloride
          References
          ReferencesManago, F., et al. 2013. Psychopharmacol. (Berl) 226, 541.
          Cavas, M., et al. 2013. Prog. Neuropsychopharmacol. Biol. Psychiatry. 40, 18.
          Micheli, F., 2000. Cur. Op. Invest. Drugs (London, England) 1, 355.
          Li, X., et al. 2006. J. Pharmacol. & Exp. Therapeutics. 319, 254.
          Tatarczyñska, E., et al. 2001. Bri. J. Pharmacol. 132, 1423.
          Product Information
          CAS number96206-92-7
          FormWhite solid
          Hill FormulaC₁₄H₁₁N Å• HCl
          Chemical formulaC₁₄H₁₁N Å• HCl
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Primary TargetmGlu₅ receptors
          Purity≥99% by HPLC
          Physicochemical Information
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
          Toxicity Standard Handling
          Storage +2°C to +8°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze 9-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          MPEP Hydrochloride - CAS 96206-92-7 - Calbiochem SDS

          Title

          Safety Data Sheet (SDS) 

          References

          Reference overview
          Manago, F., et al. 2013. Psychopharmacol. (Berl) 226, 541.
          Cavas, M., et al. 2013. Prog. Neuropsychopharmacol. Biol. Psychiatry. 40, 18.
          Micheli, F., 2000. Cur. Op. Invest. Drugs (London, England) 1, 355.
          Li, X., et al. 2006. J. Pharmacol. & Exp. Therapeutics. 319, 254.
          Tatarczyñska, E., et al. 2001. Bri. J. Pharmacol. 132, 1423.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision28-June-2013 JSW
          Synonyms6-Methyl-2-(phenylethynyl)pyridine hydrochloride
          DescriptionA non-competitive, highly potent antagonist selective for mGlu5 receptors (IC50 = 36 nM). Also a positive allosteric modulator of mGlu4and weak anatagonist of NMDA receptors. Biologically active admitted systematically. Widely used in assessing the functional roles of mGlu5 receptors in a variety of research areas, such as learning and memory, sleep, neuroprotection, depression, addiction, anxiety and stress related disorders, analgesia, locomotion, neural plasticity, and Parkinson's disease.
          FormWhite solid
          CAS number96206-92-7
          Chemical formulaC₁₄H₁₁N Å• HCl
          Structure formulaStructure formula
          Purity≥99% by HPLC
          SolubilityDMSO (100 mM)
          Storage +2°C to +8°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze 9-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Standard Handling
          ReferencesManago, F., et al. 2013. Psychopharmacol. (Berl) 226, 541.
          Cavas, M., et al. 2013. Prog. Neuropsychopharmacol. Biol. Psychiatry. 40, 18.
          Micheli, F., 2000. Cur. Op. Invest. Drugs (London, England) 1, 355.
          Li, X., et al. 2006. J. Pharmacol. & Exp. Therapeutics. 319, 254.
          Tatarczyñska, E., et al. 2001. Bri. J. Pharmacol. 132, 1423.