444274 MMP-2/MMP-9 Inhibitor IV - CAS 292605-14-2 - Calbiochem

444274
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₁₅H₁₄O₃S₂ 292605-14-2

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      444274-500UG
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          Plastic ampoule 500 μg
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          Description
          OverviewA potent, selective, slow-binding and mechanism-based inhibitor of human gelatinases, MMP-2 (Ki = 13.9 nM), and MMP-9 (Ki = 600 nM). This inhibitor appears to behave similarly to TIMP-1 and TIMP-2 in the slow-binding component of inhibition. Also exhibits a covalent mechanism-based behavior in inhibition of these enzymes. Binds directly to the catalytic zinc ion on MMP-2.
          Catalogue Number444274
          Brand Family Calbiochem®
          SynonymsSB-3CT
          References
          ReferencesKrüger, A., et al. 2005. Cancer Res. 65, 3523.
          Kleinfeld, O., et al. 2001. J. Biol. Chem. 276, 17125.
          Brown, S., et al. 2000. J. Am. Chem. Soc. 122, 6799.
          Product Information
          CAS number292605-14-2
          ATP CompetitiveN
          DeclarationSold under license of U.S. Patent 6,703,415.
          FormOff-white solid
          Hill FormulaC₁₅H₁₄O₃S₂
          Chemical formulaC₁₅H₁₄O₃S₂
          ReversibleN
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Primary TargetMMP-2
          Primary Target K<sub>i</sub>13.9 nM
          Purity≥ 95% by HPLC
          Physicochemical Information
          Cell permeableN
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage -20°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          444274

          References

          Reference overview
          Krüger, A., et al. 2005. Cancer Res. 65, 3523.
          Kleinfeld, O., et al. 2001. J. Biol. Chem. 276, 17125.
          Brown, S., et al. 2000. J. Am. Chem. Soc. 122, 6799.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision13-April-2011 RFH
          SynonymsSB-3CT
          DescriptionA potent, selective, slow-binding and mechanism-based inhibitor of human gelatinases, MMP-2 (Ki = 13.9 nM) and MMP-9 (Ki = 600 nM). It also exhibits a covalent mechanism based behavior in inhibition of these enzymes. This inhibitor appears to have similarity to TIMP-1 and TIMP-2 in the slow-binding component of inhibition. Shown to directly bind to the zinc in the catalytic site of MMP-2. Does not affect the activities of MMP-1 (Ki = 206 µM) MMP-3 (Ki = 15 µM), or MMP-7 (Ki = 96 µM).
          FormOff-white solid
          Intert gas (Yes/No) Packaged under inert gas
          CAS number292605-14-2
          Chemical formulaC₁₅H₁₄O₃S₂
          Structure formulaStructure formula
          Purity≥ 95% by HPLC
          SolubilityDMSO (100 mg/ml)
          Storage -20°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
          Toxicity Standard Handling
          ReferencesKrüger, A., et al. 2005. Cancer Res. 65, 3523.
          Kleinfeld, O., et al. 2001. J. Biol. Chem. 276, 17125.
          Brown, S., et al. 2000. J. Am. Chem. Soc. 122, 6799.