444244 MMP-2 Inhibitor I - CAS 10335-69-0 - Calbiochem

444244
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₁₈H₃₅NO₂ 10335-69-0

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      444244-10MG
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          Plastic ampoule 10 mg
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          Description
          OverviewA cell-permeable, potent inhibitor of MMP-2 that acts in a dose-dependent manner (Ki = 1.7 µM).
          Catalogue Number444244
          Brand Family Calbiochem®
          Synonymscis-9-Octadecenoyl-N-hydroxylamide, Oleoyl-N-hydroxylamide, OA-Hy
          References
          ReferencesBerton, A., et. al. 2001. J. Biol. Chem. 276, 20458.
          Emonard, H., et al. 1999. Ann. N.Y. Acad. Sci. 878, 647.
          Product Information
          CAS number10335-69-0
          ATP CompetitiveN
          FormWhite solid
          Hill FormulaC₁₈H₃₅NO₂
          Chemical formulaC₁₈H₃₅NO₂
          ReversibleN
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Primary TargetMMP-2
          Primary Target K<sub>i</sub>1.7 mM
          Purity≥98% by TLC
          Physicochemical Information
          Cell permeableY
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Blue Ice Only
          Toxicity Standard Handling
          Storage -20°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsUnstable in solution; reconstitute just prior to use.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          444244

          References

          Reference overview
          Berton, A., et. al. 2001. J. Biol. Chem. 276, 20458.
          Emonard, H., et al. 1999. Ann. N.Y. Acad. Sci. 878, 647.

          Citations

          Title
        • Anthony R. White, et al. (2006) Degradation of the alzheimer disease amyloid -peptide by metal-dependent up-regulation of metalloprotease activity. journal of Biological Chemistry 281, 17670-17680.
        • Michelle K.Y. Siu and C. Yan Cheng. (2004) Interactions of proteases, protease inhibitors, and the β1 integrin/laminin γ3 protein complex in the regulation of ectoplasmic specialization dynamics in the rat testis. Biology of Reproduction 70, 945-964.
        • Feng Zheng, et al. (2004) Development of albuinuria and glomerular lesions in normoglycemic B6 recepients of db/db mice bone marrow. Diabetes 53, 2420-2427.
        • Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision03-April-2008 RFH
          Synonymscis-9-Octadecenoyl-N-hydroxylamide, Oleoyl-N-hydroxylamide, OA-Hy
          DescriptionPotent inhibitor of MMP-2 (gelatinase A). Inhibits MMP-2 in a dose dependent manner (Ki = 1.7 µM)
          FormWhite solid
          Intert gas (Yes/No) Packaged under inert gas
          CAS number10335-69-0
          Chemical formulaC₁₈H₃₅NO₂
          Structure formulaStructure formula
          Purity≥98% by TLC
          SolubilityDMSO (2 mg/ml) or Ethanol (3 mg/ml)
          Storage -20°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsUnstable in solution; reconstitute just prior to use.
          Toxicity Standard Handling
          ReferencesBerton, A., et. al. 2001. J. Biol. Chem. 276, 20458.
          Emonard, H., et al. 1999. Ann. N.Y. Acad. Sci. 878, 647.
          Citation
        • Anthony R. White, et al. (2006) Degradation of the alzheimer disease amyloid -peptide by metal-dependent up-regulation of metalloprotease activity. journal of Biological Chemistry 281, 17670-17680.
        • Michelle K.Y. Siu and C. Yan Cheng. (2004) Interactions of proteases, protease inhibitors, and the β1 integrin/laminin γ3 protein complex in the regulation of ectoplasmic specialization dynamics in the rat testis. Biology of Reproduction 70, 945-964.
        • Feng Zheng, et al. (2004) Development of albuinuria and glomerular lesions in normoglycemic B6 recepients of db/db mice bone marrow. Diabetes 53, 2420-2427.