444283 MMP-13 Inhibitor - CAS 544678-85-5 - Calbiochem

444283
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₂₂H₂₀F₂N₄O₂ 544678-85-5

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      444283-1MG
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          Plastic ampoule 1 mg
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          Description
          OverviewA pyrimidine dicarboxamide compound that potently inhibits MMP-13 activity (IC50 = 8 nM) with expected selectivity over MMP-1, -2, -3, -7, -8, -9, -10, -12, -14 and -16 as determined by conformational structure analysis. Shown to bind to the MMP-13 catalytic domain and act as a non-zinc-chelating inhibitor.
          Catalogue Number444283
          Brand Family Calbiochem®
          SynonymsPyrimidine-4,6-dicarboxylic acid, bis-(4-fluoro-3-methyl-benzylamide)
          References
          ReferencesEngel, C.K., et al. 2005. Chem. Biol. 12, 181.
          Product Information
          CAS number544678-85-5
          ATP CompetitiveN
          FormLight yellow solid
          Hill FormulaC₂₂H₂₀F₂N₄O₂
          Chemical formulaC₂₂H₂₀F₂N₄O₂
          ReversibleN
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Primary TargetMMP-13 activity
          Primary Target IC<sub>50</sub>8 nM against MMP-13
          Purity≥98% by HPLC
          Physicochemical Information
          Cell permeableN
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
          Toxicity Standard Handling
          Storage +2°C to +8°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          444283

          References

          Reference overview
          Engel, C.K., et al. 2005. Chem. Biol. 12, 181.

          Brochure

          Title
          Biologics 32.4 ( 1.19 MB )
          Calbiochem Biologics 32.2
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision07-August-2008 RFH
          SynonymsPyrimidine-4,6-dicarboxylic acid, bis-(4-fluoro-3-methyl-benzylamide)
          DescriptionA potent inhibitor of MMP-13 activity (IC50 = 8 nM) with expected selectivity over MMP-1, -2, -3, -7, -8, -9, -10, -12, -14 and -16 as determined by conformational structure analysis. Shown to bind to the MMP-13 catalytic domain and act as a non-zinc-chelating inhibitor.
          FormLight yellow solid
          Intert gas (Yes/No) Packaged under inert gas
          CAS number544678-85-5
          Chemical formulaC₂₂H₂₀F₂N₄O₂
          Structure formulaStructure formula
          Purity≥98% by HPLC
          SolubilityDMSO (10 mg/ml). Further dilute in buffer immediately prior to use.
          Storage +2°C to +8°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
          Toxicity Standard Handling
          ReferencesEngel, C.K., et al. 2005. Chem. Biol. 12, 181.