444965 MEK Inhibitor VIII - CAS 212631-61-3 - Calbiochem

444965
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₁₈H₁₆F₃IN₂O₂ 212631-61-3

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      444965-5MG
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          Plastic ampoule 5 mg
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          Description
          OverviewA cell-permeable and orally available amino-benzamide compound that acts as a potent and non-ATP-competitive inhibitor of MEK1/2 (IC50 = 8 nM) with an excellent selectivity over ERK, c-Src, Cdk's, and PI 3-Kγ (IC50 >1.0 µM). Reported to exhibit in vivo efficacy in several animal models of arthritis and hyperalgesia in rat and rabbit.
          Catalogue Number444965
          Brand Family Calbiochem®
          SynonymsN-Cyclopropylmethoxy-3,4,5-trifluoro-2-(4-iodo-2-methylphenylamino)benzamide
          References
          ReferencesPelletier, J.P., et al. 2003. Arthritis Rheum. 48, 1582.
          Ciruela, A., et al. 2003. Br. J. Pharmacol. 138, 751.
          Bhattachar, S.N., et al. 2002. Int. J. Pharm. 236, 135.
          Product Information
          CAS number212631-61-3
          FormWhite solid
          Hill FormulaC₁₈H₁₆F₃IN₂O₂
          Chemical formulaC₁₈H₁₆F₃IN₂O₂
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Purity≥98% by HPLC
          Physicochemical Information
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          S PhraseS: 22-24/25-36/37/39

          Do not breathe dust.
          Avoid contact with skin and eyes.
          Wear suitable protective clothing, gloves and eye/face protection.
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage +2°C to +8°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          444965

          References

          Reference overview
          Pelletier, J.P., et al. 2003. Arthritis Rheum. 48, 1582.
          Ciruela, A., et al. 2003. Br. J. Pharmacol. 138, 751.
          Bhattachar, S.N., et al. 2002. Int. J. Pharm. 236, 135.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision17-December-08 RFH
          SynonymsN-Cyclopropylmethoxy-3,4,5-trifluoro-2-(4-iodo-2-methylphenylamino)benzamide
          DescriptionA cell-permeable and orally available amino-benzamide compound that acts as a potent and non-ATP-competitive inhibitor of MEK1/2 (IC50 = 8 nM) with an excellent selectivity over ERK, c-Src, Cdk's, and PI 3-Kγ (IC50 >1.0 µM). Reported to exhibit in vivo efficacy in several animal models of arthritis and hyperalgesia in rat and rabbit.
          FormWhite solid
          Intert gas (Yes/No) Packaged under inert gas
          CAS number212631-61-3
          Chemical formulaC₁₈H₁₆F₃IN₂O₂
          Structure formulaStructure formula
          Purity≥98% by HPLC
          SolubilityDMSO (45 mg/ml) or Ethanol (45 mg/ml)
          Storage +2°C to +8°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Standard Handling
          ReferencesPelletier, J.P., et al. 2003. Arthritis Rheum. 48, 1582.
          Ciruela, A., et al. 2003. Br. J. Pharmacol. 138, 751.
          Bhattachar, S.N., et al. 2002. Int. J. Pharm. 236, 135.