438185 Lovastatin - CAS 75330-75-5 - Calbiochem

438185
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₂₄H₃₆O₅ 75330-75-5

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      438185-25MG
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          Plastic ampoule 25 mg
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          Description
          OverviewAn anti-hypercholesterolemic agent that inhibits the activity of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase. Has been shown to block a series of biological events including: the activation of p21ras by insulin in 3T3-L1 fibroblasts and 3T3-L1 adipocytes; the farnesylation of p21ras, which decreases the pool of intracellular Ras available for subsequent activation by growth factors (including insulin); and N-ras-induced neuronal differentiation. Causes cell cycle arrest in the late G1 phase through inhibition of proteasome. Has recently been shown to inhibit the stimulation of MAP kinase by insulin in HIRcB cells and to block the transcription of type-I SCR gene in THP-1-derived macrophages. Also blocks PDGF receptor tyrosine phosphorylation and MAP kinase activation by PDGF. This product requires activation for use in cell synchronization studies and in cell-free assay systems for HMG-CoA studies.
          Catalogue Number438185
          Brand Family Calbiochem®
          SynonymsMevinolin, MK-803, L-Type Calcium Channel Blocker IV
          References
          ReferencesRao, S., et al. 1999. Proc. Natl. Acad. Sci. USA 96, 7197.
          Carel, K., et al. 1996. J. Biol. Chem. 271, 30625.
          McGuire, T.F., et al. 1996. J. Biol. Chem. 271, 27402.
          Umetani, N., et al. 1996. Biochim. Biophys. Acta 1303, 199.
          Xu, X.Q., et al. 1996. Arch. Biochem. Biophys. 326, 233.
          Reusch, J.E.-B., et al. 1995. J. Biol. Chem. 270, 2036.
          Jakobisiak, M., et al. 1991. Proc. Natl. Acad. Sci. USA 88, 3628.
          Keyomarsi, K., et al. 1991. Cancer Res. 51, 3602.
          Mendola, C.E., and Backer, J.M. 1990. Cell Growth Differ. 1, 499.
          Product Information
          CAS number75330-75-5
          ATP CompetitiveN
          FormWhite to off-white powder
          Hill FormulaC₂₄H₃₆O₅
          Chemical formulaC₂₄H₃₆O₅
          ReversibleN
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Primary TargetActivity of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase
          Purity≥95% by HPLC
          Physicochemical Information
          Cell permeableN
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          RTECSEK7907000
          Safety Information
          R PhraseR: 63

          Possible risk of harm to the unborn child.
          S PhraseS: 22-24/25

          Do not breathe dust.
          Avoid contact with skin and eyes.
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Carcinogenic / Teratogenic
          Storage +2°C to +8°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution aliquot, flush with an inert gas, and freeze (-20°C). Stock solutions, in high quality DMSO or ethanol are stable for up to 1 month at -20°C.
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          438185

          References

          Reference overview
          Rao, S., et al. 1999. Proc. Natl. Acad. Sci. USA 96, 7197.
          Carel, K., et al. 1996. J. Biol. Chem. 271, 30625.
          McGuire, T.F., et al. 1996. J. Biol. Chem. 271, 27402.
          Umetani, N., et al. 1996. Biochim. Biophys. Acta 1303, 199.
          Xu, X.Q., et al. 1996. Arch. Biochem. Biophys. 326, 233.
          Reusch, J.E.-B., et al. 1995. J. Biol. Chem. 270, 2036.
          Jakobisiak, M., et al. 1991. Proc. Natl. Acad. Sci. USA 88, 3628.
          Keyomarsi, K., et al. 1991. Cancer Res. 51, 3602.
          Mendola, C.E., and Backer, J.M. 1990. Cell Growth Differ. 1, 499.

          Brochure

          Title
          Biologics 32.4 ( 1.19 MB )
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision15-May-2008 RFH
          SynonymsMevinolin, MK-803, L-Type Calcium Channel Blocker IV
          DescriptionAn anti-hypercholesterolemic agent and an inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase that blocks a series of biological events including: activation of p21ras by insulin in 3T3-L1 fibroblasts and 3T3-L1 adipocytes, farnesylation of p21ras, which decreases the pool of intracellular Ras available for subsequent activation by growth factors (including insulin), and N-ras-induced neuronal differentiation. Causes cell cycle arrest in the late G1 phase. Shown to inhibit the stimulation of MAP kinase by insulin in HIRcB cells and block the transcription of the type-I SCR gene in THP-1-derived macrophages. Also blocks PDGF receptor tyrosine phosphorylation and MAP kinase activation by PDGF. This product requires activation for use in cell synchronization studies and in cell-free assay systems for HMG-CoA studies.
          FormWhite to off-white powder
          Recommended reaction conditionsActivation Protocols: Liu, Li., et al. 1999. J. Biol. Chem. 274, 33334. Keyomarsi, K., et al. 1991. Cancer Res. 51, 3602.
          CAS number75330-75-5
          RTECSEK7907000
          Chemical formulaC₂₄H₃₆O₅
          Structure formulaStructure formula
          Purity≥95% by HPLC
          SolubilityDMSO (50 mg/ml) or Ethanol (25 mg/ml)
          Storage +2°C to +8°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution aliquot, flush with an inert gas, and freeze (-20°C). Stock solutions, in high quality DMSO or ethanol are stable for up to 1 month at -20°C.
          Toxicity Carcinogenic / Teratogenic
          Merck USA index14, 5586
          ReferencesRao, S., et al. 1999. Proc. Natl. Acad. Sci. USA 96, 7197.
          Carel, K., et al. 1996. J. Biol. Chem. 271, 30625.
          McGuire, T.F., et al. 1996. J. Biol. Chem. 271, 27402.
          Umetani, N., et al. 1996. Biochim. Biophys. Acta 1303, 199.
          Xu, X.Q., et al. 1996. Arch. Biochem. Biophys. 326, 233.
          Reusch, J.E.-B., et al. 1995. J. Biol. Chem. 270, 2036.
          Jakobisiak, M., et al. 1991. Proc. Natl. Acad. Sci. USA 88, 3628.
          Keyomarsi, K., et al. 1991. Cancer Res. 51, 3602.
          Mendola, C.E., and Backer, J.M. 1990. Cell Growth Differ. 1, 499.