437720 Lipoxin A₄ - CAS 89663-86-5 - Calbiochem

437720
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₂₀H₃₂O₅ 89663-86-5

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      437720-25UG
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          Glass bottle 25 μg
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          Description
          OverviewPotent inhibitor of cytotoxic activity of human natural killer cells; shown to be as potent as LTB4 in stimulating human neutrophils to generate superoxides. Involved in contractile responses and acts as a potent activator of human protein kinase C. Stimulates rapid lipid remodeling and pertussis-sensitive release of arachidonic acid in polymorphonuclear leukocytes. Stimulates MAP kinases via activation of G protein-coupled receptors.
          Caution! Product contains volatile liquid. Keep product cold at all times.
          Catalogue Number437720
          Brand Family Calbiochem®
          SynonymsLXA₄, 5(S),6(R),15(S)-Trihydroxyeicosa-7-trans-9-trans-11-cis-13-trans-tetraenoic Acid
          References
          ReferencesMcMahon, B., et al. 2000. J. Biol. Chem. 275, 27566.
          Soyombo, O., et al. 1994. Allergy 49, 230.
          Flore, S., et al. 1992. J. Biol. Chem. 267, 16168.
          Badr, K.F., et al. 1989. Proc. Natl. Acad. Sci. USA 86, 3438.
          Product Information
          CAS number89663-86-5
          ATP CompetitiveN
          FormLiquid
          FormulationIn Ethanol.
          Hill FormulaC₂₀H₃₂O₅
          Chemical formulaC₂₀H₃₂O₅
          ReversibleN
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Primary TargetPotent inhibitor of cytotoxic activity of human natural killer cells
          Purity≥95% by HPLC
          Physicochemical Information
          Cell permeableN
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          R PhraseR: 11-36/37/38

          Highly flammable.
          Irritating to eyes, respiratory system and skin.
          S PhraseS: 16-26-36-7

          Keep away from sources of ignition - No Smoking.
          In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
          Wear suitable protective clothing.
          Keep container tightly closed.
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Dry Ice Only
          Toxicity Flammable
          Hazardous Materials Attention: Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
          Storage ≤ -70°C
          Do not freeze Ok to freeze
          Special InstructionsFollowing initial thaw, aliquot and freeze (-70°C).
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          437720

          References

          Reference overview
          McMahon, B., et al. 2000. J. Biol. Chem. 275, 27566.
          Soyombo, O., et al. 1994. Allergy 49, 230.
          Flore, S., et al. 1992. J. Biol. Chem. 267, 16168.
          Badr, K.F., et al. 1989. Proc. Natl. Acad. Sci. USA 86, 3438.

          Brochure

          Title
          Bioactive Lipids Technical Bulletin
          MAPK Pathway Poster ( 750 KB )
          PKC Pathway Poster PDF ( 676 KB )
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision06-August-2008 RFH
          SynonymsLXA₄, 5(S),6(R),15(S)-Trihydroxyeicosa-7-trans-9-trans-11-cis-13-trans-tetraenoic Acid
          DescriptionPotent inhibitor of cytotoxic activity of human natural killer cells. Shown to be as potent as LTB4 in stimulating human neutrophils to generate superoxides. Involved in contractile responses and acts as a potent enhancer of human protein kinase C. Stimulates the rapid lipid remodeling and pertussis-sensitive release of arachidonic acid in polymorphonuclear leukocytes.
          FormLiquid
          FormulationIn Ethanol.
          CAS number89663-86-5
          Chemical formulaC₂₀H₃₂O₅
          Structure formulaStructure formula
          Purity≥95% by HPLC
          SolubilityEthanol
          Storage ≤ -70°C
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing initial thaw, aliquot and freeze (-70°C).
          Toxicity Flammable
          ReferencesMcMahon, B., et al. 2000. J. Biol. Chem. 275, 27566.
          Soyombo, O., et al. 1994. Allergy 49, 230.
          Flore, S., et al. 1992. J. Biol. Chem. 267, 16168.
          Badr, K.F., et al. 1989. Proc. Natl. Acad. Sci. USA 86, 3438.