437725 Lipoxin A₄, 15-epi - CAS 171030-11-8 - Calbiochem

437725
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₂₀H₃₂O₅ 171030-11-8

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      437725-25UG
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      Discontinued
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          Glass bottle 25 μg
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          Description
          OverviewA epimeric lipoxin A4 (Cat. No. 437720) analog that is more potent and metabolically stable than LXA4. Exhibits anti-inflammatory properties and serves as a "stop signal" to excessive leukocyte trafficking/infiltration. Blocks TNF-α-induced IL-8 release in human enterocyte. It is also an important modulator of the many pharmacological actions caused by aspirin.
          Caution! Product contains volatile liquid. Keep product cold at all times.
          Catalogue Number437725
          Brand Family Calbiochem®
          SynonymsLXA₄-15-epi, 15(R)-LXA₄, Aspirin-triggered LXA₄, (5S,6R,15R)-5,6,15-Trihydroxy-7,9,13-trans-11-cis-eicosatetraenoic acid
          References
          ReferencesWallace, J.L., and Fiorucci, S. 2003. Trends Pharmacol. Sci. 24, 323.
          Filep, J.G., et al. 2002. Adv. Exp. Med. Biol. 507, 223.
          Titos, E., et al. 1999. Am. J. Physiol. 277, C870.
          Gronert, K., et al. 1998. J. Exp. Med. 187, 1285.
          Maddox, J.F., et al. 1997. J. Biol. Chem. 272, 6972.
          Claria, J., et al. 1996. Mol. Med. 2, 583.
          Claria, J., and Serhan, C.N. 1995. Proc. Natl. Acad. Sci. USA 92, 9475.
          Serhan, C.N., et al. 1995. Biochemistry 34, 14609.
          Product Information
          CAS number171030-11-8
          ATP CompetitiveN
          FormLiquid
          FormulationIn Ethanol.
          Hill FormulaC₂₀H₃₂O₅
          Chemical formulaC₂₀H₃₂O₅
          Hygroscopic Hygroscopic
          ReversibleN
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Primary TargetExhibits anti-inflammatory properties
          Purity≥98% by HPLC
          Physicochemical Information
          Cell permeableN
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Dry Ice Only
          Toxicity Flammable
          Hazardous Materials Attention: Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
          Storage ≤ -70°C
          Protect from Light Protect from light
          Hygroscopic Hygroscopic
          Do not freeze Ok to freeze
          Special InstructionsFollowing initial thaw aliquot and freeze (-70°C).
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          437725

          References

          Reference overview
          Wallace, J.L., and Fiorucci, S. 2003. Trends Pharmacol. Sci. 24, 323.
          Filep, J.G., et al. 2002. Adv. Exp. Med. Biol. 507, 223.
          Titos, E., et al. 1999. Am. J. Physiol. 277, C870.
          Gronert, K., et al. 1998. J. Exp. Med. 187, 1285.
          Maddox, J.F., et al. 1997. J. Biol. Chem. 272, 6972.
          Claria, J., et al. 1996. Mol. Med. 2, 583.
          Claria, J., and Serhan, C.N. 1995. Proc. Natl. Acad. Sci. USA 92, 9475.
          Serhan, C.N., et al. 1995. Biochemistry 34, 14609.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision06-August-2008 RFH
          SynonymsLXA₄-15-epi, 15(R)-LXA₄, Aspirin-triggered LXA₄, (5S,6R,15R)-5,6,15-Trihydroxy-7,9,13-trans-11-cis-eicosatetraenoic acid
          DescriptionAn epimeric lipoxin A4 (Cat. No. 437720) analog that is more potent and metabolically stable than LXA4. Exhibits anti-inflammatory properties and serves as a "stop signal" to excessive leukocyte trafficking/infiltration. Reported to block TNF-α-induced IL-8 release in human enterocytes. Also reported to be an important modulator of the pharmacological actions of aspirin.

          Caution! Product contains volatile liquid; keep cold at all times.
          FormLiquid
          FormulationIn Ethanol.
          Intert gas (Yes/No) Packaged under inert gas
          CAS number171030-11-8
          Chemical formulaC₂₀H₃₂O₅
          Structure formulaStructure formula
          Purity≥98% by HPLC
          Storage ≤ -70°C
          Hygroscopic
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing initial thaw aliquot and freeze (-70°C).
          Toxicity Flammable
          ReferencesWallace, J.L., and Fiorucci, S. 2003. Trends Pharmacol. Sci. 24, 323.
          Filep, J.G., et al. 2002. Adv. Exp. Med. Biol. 507, 223.
          Titos, E., et al. 1999. Am. J. Physiol. 277, C870.
          Gronert, K., et al. 1998. J. Exp. Med. 187, 1285.
          Maddox, J.F., et al. 1997. J. Biol. Chem. 272, 6972.
          Claria, J., et al. 1996. Mol. Med. 2, 583.
          Claria, J., and Serhan, C.N. 1995. Proc. Natl. Acad. Sci. USA 92, 9475.
          Serhan, C.N., et al. 1995. Biochemistry 34, 14609.