435800 Licochalcone-A, Synthetic - CAS 58749-22-7 - Calbiochem

435800
Price could not be retrieved
Minimum Quantity needs to be mulitiple of
Upon Order Completion More Information
You Saved ()
 
Request Pricing
Limited AvailabilityLimited Availability
Stocked 
Discontinued
Limited Quantities Available
Available
    Remaining : Will advise
      Remaining : Will advise
      Will advise
      Contact Customer Service
      Contact Customer Service
      View Pricing & Availability
      Click To Print This Page

      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₂₁H₂₂O₄ 58749-22-7

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      435800-10MG
      Retrieving availability...
      Limited AvailabilityLimited Availability
      Stocked 
      Discontinued
      Limited Quantities Available
      Available
        Remaining : Will advise
          Remaining : Will advise
          Will advise
          Contact Customer Service
          Contact Customer Service

          Plastic ampoule 10 mg
          Retrieving price...
          Price could not be retrieved
          Minimum Quantity needs to be mulitiple of
          Upon Order Completion More Information
          You Saved ()
           
          Request Pricing
          435800-50MG
          Retrieving availability...
          Limited AvailabilityLimited Availability
          Stocked 
          Discontinued
          Limited Quantities Available
          Available
            Remaining : Will advise
              Remaining : Will advise
              Will advise
              Contact Customer Service
              Contact Customer Service

              Plastic ampoule 50 mg
              Retrieving price...
              Price could not be retrieved
              Minimum Quantity needs to be mulitiple of
              Upon Order Completion More Information
              You Saved ()
               
              Request Pricing
              Description
              OverviewAn estrogenic flavonoid with anti-tumor and antiparasitic properties. Shown to reduce Bcl-2 protein expression and induce apoptosis in several human cancer cell lines. Also induces cell differentiation, exhibits anti-tumor activity, and enhances the effect of Paclitaxel (Cat. No. 580555) and Vinblastine (Cat. No. 677175) chemotherapy. Reported to interfere with parasite mitochondrial electron transport chain and energy metabolism.
              Catalogue Number435800
              Brand Family Calbiochem®
              Synonyms(E)-3-[5-(1,1-Dimethyl-2-propenyl)-4-hydroxy-2-methoxyphenyl]-1-(4-hydroxyphenyl)-2-propen-1-one
              References
              ReferencesRafi, M.M., et al. 2000. Anticancer Res. 20, 2653.
              Zhai, L., et al. 1999. J. Antimicrob. Chemother. 43, 793.
              Haraguchi, H., et al. 1998. Phytochemistry 48, 125.
              Park, E.J., et al. 1998. Planta Med. 64, 464.
              Chen, M., et al. 1994. Antimicrob. Agents Chemother. 38, 1470.
              Chen, M., et al. 1993. Antimicrob. Agents. Chemother. 37, 2550.
              Product Information
              CAS number58749-22-7
              ATP CompetitiveN
              FormYellow solid
              Hill FormulaC₂₁H₂₂O₄
              Chemical formulaC₂₁H₂₂O₄
              ReversibleN
              Structure formula ImageStructure formula Image
              Applications
              ApplicationLicochalcone-A, Synthetic, CAS 58749-22-7, is an estrogenic flavonoid with anti-tumor & antiparasitic properties. Reduces Bcl-2 expression and induces apoptosis in several human cancer cell lines.
              Biological Information
              Primary TargetAnti-tumor and antiparasitic properties
              Purity≥96% by HPLC
              Physicochemical Information
              Cell permeableN
              Dimensions
              Materials Information
              Toxicological Information
              Safety Information according to GHS
              Safety Information
              R PhraseR: 20/21/22

              Harmful by inhalation, in contact with skin and if swallowed.
              S PhraseS: 36

              Wear suitable protective clothing.
              Product Usage Statements
              Storage and Shipping Information
              Ship Code Ambient Temperature Only
              Toxicity Harmful
              Storage -20°C
              Protect from Light Protect from light
              Do not freeze Ok to freeze
              Special InstructionsFollowing reconstitution aliquot and freeze at -20°C. Stock solutions are stable for up to 6 months at -20°C.
              Packaging Information
              Packaged under inert gas Packaged under inert gas
              Transport Information
              Supplemental Information
              Specifications

              Documentation

              SDS

              Title

              Safety Data Sheet (SDS) 

              Certificates of Analysis

              TitleLot Number
              435800

              References

              Reference overview
              Rafi, M.M., et al. 2000. Anticancer Res. 20, 2653.
              Zhai, L., et al. 1999. J. Antimicrob. Chemother. 43, 793.
              Haraguchi, H., et al. 1998. Phytochemistry 48, 125.
              Park, E.J., et al. 1998. Planta Med. 64, 464.
              Chen, M., et al. 1994. Antimicrob. Agents Chemother. 38, 1470.
              Chen, M., et al. 1993. Antimicrob. Agents. Chemother. 37, 2550.
              Data Sheet

              Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

              Revision05-August-2008 RFH
              Synonyms(E)-3-[5-(1,1-Dimethyl-2-propenyl)-4-hydroxy-2-methoxyphenyl]-1-(4-hydroxyphenyl)-2-propen-1-one
              DescriptionAn estrogenic flavanoid with anti-tumor and anti-parasitic properties. Shown to reduce Bcl-2 protein expression and induce apoptosis in several human cancer cell lines. Also induces cell differentiation and enhances the effect of paclitaxel and vinblastine chemotherapy. Reported to interfere with parasite mitochondrial electron transport chain and energy metabolism.
              FormYellow solid
              Intert gas (Yes/No) Packaged under inert gas
              CAS number58749-22-7
              Chemical formulaC₂₁H₂₂O₄
              Structure formulaStructure formula
              Purity≥96% by HPLC
              SolubilityDMSO (10 mg/ml) or Ethanol. Further dilute 1:10 with aqueous buffer or medium just prior to use.
              Storage -20°C
              Protect from light
              Do Not Freeze Ok to freeze
              Special InstructionsFollowing reconstitution aliquot and freeze at -20°C. Stock solutions are stable for up to 6 months at -20°C.
              Toxicity Harmful
              ReferencesRafi, M.M., et al. 2000. Anticancer Res. 20, 2653.
              Zhai, L., et al. 1999. J. Antimicrob. Chemother. 43, 793.
              Haraguchi, H., et al. 1998. Phytochemistry 48, 125.
              Park, E.J., et al. 1998. Planta Med. 64, 464.
              Chen, M., et al. 1994. Antimicrob. Agents Chemother. 38, 1470.
              Chen, M., et al. 1993. Antimicrob. Agents. Chemother. 37, 2550.