440203 LY 303511 - CAS 154447-38-8 - Calbiochem
A cell-permeable negative control for the PI 3-kinase inhibitor LY 294002.
More>> A cell-permeable negative control for the PI 3-kinase inhibitor LY 294002. Less<<LY 303511 - CAS 154447-38-8 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Synonyms: 2-Piperazinyl-8-phenyl-4H-1-benzopyran-4-one, BRD2 Inhibitor V, BRD3 Inhibitor IV, BRD4 Inhibitor V
Overview
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Key Specifications Table
Empirical Formula | CAS # |
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C₁₉H₁₈N₂O₂ | 154447-38-8 |
Pricing & Availability
Catalog Number | Availability | Packaging | Qty/Pack | Price | Quantity | |
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440203-1MG |
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Plastic ampoule | 1 mg |
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Description | |
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Overview | A cell-permeable negative control for the PI 3-kinase inhibitor LY 294002 (Cat. No. 440202). Contains a single atom substitution in the morpholine ring compared to LY 294002. Does not inhibit PI 3-kinase even at a concentration of 100 µM. Shown to bind to the same site as I-BET (Cat. no. 401010) and reversibly inhibit BET bromodomain proteins BRD2, BRD3 & BRD4 (IC50 ~10 µM). |
Catalogue Number | 440203 |
Brand Family | Calbiochem® |
Synonyms | 2-Piperazinyl-8-phenyl-4H-1-benzopyran-4-one, BRD2 Inhibitor V, BRD3 Inhibitor IV, BRD4 Inhibitor V |
References | |
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References | Dittman, et al. 2014. ACS Chem Biol. 9, 495. Ding, J., et al. 1995. J. Biol. Chem. 270, 11684. Vlahos, C.J., et al. 1994. J. Biol. Chem. 269, 5241. |
Product Information | |
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CAS number | 154447-38-8 |
ATP Competitive | N |
Form | Amber solid |
Hill Formula | C₁₉H₁₈N₂O₂ |
Chemical formula | C₁₉H₁₈N₂O₂ |
Reversible | N |
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Cell permeable | Y |
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Documentation
SDS
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Certificates of Analysis
Title | Lot Number |
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440203 |
References
Reference overview |
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Dittman, et al. 2014. ACS Chem Biol. 9, 495. Ding, J., et al. 1995. J. Biol. Chem. 270, 11684. Vlahos, C.J., et al. 1994. J. Biol. Chem. 269, 5241. |
Brochure
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