422708 KN-93 - CAS 139298-40-1 - Calbiochem

422708
Price could not be retrieved
Minimum Quantity needs to be mulitiple of
Upon Order Completion More Information
You Saved ()
 
Request Pricing
Limited AvailabilityLimited Availability
Stocked 
Discontinued
Limited Quantities Available
Available
    Remaining : Will advise
      Remaining : Will advise
      Will advise
      Contact Customer Service
      Contact Customer Service
      View Pricing & Availability
      Click To Print This Page

      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₂₆H₂₉CIN₂O₄S 139298-40-1

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      422708-1MG
      Retrieving availability...
      Limited AvailabilityLimited Availability
      Stocked 
      Discontinued
      Limited Quantities Available
      Available
        Remaining : Will advise
          Remaining : Will advise
          Will advise
          Contact Customer Service
          Contact Customer Service

          Plastic ampoule 1 mg
          Retrieving price...
          Price could not be retrieved
          Minimum Quantity needs to be mulitiple of
          Upon Order Completion More Information
          You Saved ()
           
          Request Pricing
          422708-5MG
          Retrieving availability...
          Limited AvailabilityLimited Availability
          Stocked 
          Discontinued
          Limited Quantities Available
          Available
            Remaining : Will advise
              Remaining : Will advise
              Will advise
              Contact Customer Service
              Contact Customer Service

              Plastic ampoule 5 mg
              Retrieving price...
              Price could not be retrieved
              Minimum Quantity needs to be mulitiple of
              Upon Order Completion More Information
              You Saved ()
               
              Request Pricing
              Description
              OverviewA cell-permeable, reversible and competitive inhibitor of rat brain CaM kinase II (Ki = 370 nM). Selectively binds to the CaM binding site of the enzyme and prevents the association of CaM with CaMKII. Has no significant effects on protein kinase A activity. Induces G1 cell cycle arrest and apoptosis in NIH/3T3 cells. A 5 mM (1 mg/399 µl) solution of KN-93 (Cat. No. 422712) in DMSO is also available.
              Catalogue Number422708
              Brand Family Calbiochem®
              Synonyms2-[N-(2-hydroxyethyl)]-N-(4-methoxybenzenesulfonyl)]amino-N-(4-chlorocinnamyl)-N-methylbenzylamine)
              References
              ReferencesFan, G.H., et al. 1999. Mol. Pharmacol. 56, 39.
              Tombes, R.M., et al. 1995. Cell Growth Differ. 6, 1063.
              Mamiya, N., et al. 1993. Biochem. Biophys. Res. Commun. 195, 608.
              Nicki, I., et al. 1993. Biochem. Biophys. Res. Commun. 191, 255.
              Sumi, M., et al. 1991. Biochem. Biophys. Res. Commun. 181, 968.
              Tokumitsu, H., et al. 1990. J. Biol. Chem. 265, 4315.
              Product Information
              CAS number139298-40-1
              ATP CompetitiveY
              FormOff-white solid
              Hill FormulaC₂₆H₂₉CIN₂O₄S
              Chemical formulaC₂₆H₂₉CIN₂O₄S
              ReversibleY
              Structure formula ImageStructure formula Image
              Applications
              ApplicationKN-93, CAS 139298-40-1, is a cell-permeable, reversible and competitive inhibitor of CaM kinase II (Ki = 370 nM). Binds to the CaM binding site and prevents the association of CaM with CaMKII.
              Biological Information
              Primary Targetcam kinase 2
              Primary Target K<sub>i</sub>370 nM against rat brain CaM kinase II
              Purity≥95% by HPLC
              Physicochemical Information
              Cell permeableY
              Dimensions
              Materials Information
              Toxicological Information
              Safety Information according to GHS
              Safety Information
              R PhraseR: 36/37/38

              Irritating to eyes, respiratory system and skin.
              S PhraseS: 26-36

              In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
              Wear suitable protective clothing.
              Product Usage Statements
              Storage and Shipping Information
              Ship Code Ambient Temperature Only
              Toxicity Irritant
              Storage +2°C to +8°C
              Protect from Light Protect from light
              Do not freeze Ok to freeze
              Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 4 months at -20°C.
              Packaging Information
              Transport Information
              Supplemental Information
              Specifications

              Documentation

              SDS

              Title

              Safety Data Sheet (SDS) 

              Certificates of Analysis

              TitleLot Number
              422708

              References

              Reference overview
              Fan, G.H., et al. 1999. Mol. Pharmacol. 56, 39.
              Tombes, R.M., et al. 1995. Cell Growth Differ. 6, 1063.
              Mamiya, N., et al. 1993. Biochem. Biophys. Res. Commun. 195, 608.
              Nicki, I., et al. 1993. Biochem. Biophys. Res. Commun. 191, 255.
              Sumi, M., et al. 1991. Biochem. Biophys. Res. Commun. 181, 968.
              Tokumitsu, H., et al. 1990. J. Biol. Chem. 265, 4315.

              Brochure

              Title
              Calmodulin and Related Products Technical Bulletin
              Data Sheet

              Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

              Revision25-November-2009 RFH
              Synonyms2-[N-(2-hydroxyethyl)]-N-(4-methoxybenzenesulfonyl)]amino-N-(4-chlorocinnamyl)-N-methylbenzylamine)
              DescriptionCell-permeable, reversible, and competitive inhibitor of rat brain Ca+2/calmodulin-dependent protein kinase II (Ki = 370 nM). KN-93 selectively binds to the Calmodulin (CaM) binding site of the enzyme and prevents the association of CaM with CaM Kinase II. Selectively binds to the CaM binding site of the enzyme and prevents the association of CaM with CaMKII. Has no significant effect on protein kinase A activity. Induces G1 cell cycle arrest and apoptosis in NIH 3T3 cells.
              FormOff-white solid
              CAS number139298-40-1
              Chemical formulaC₂₆H₂₉CIN₂O₄S
              Structure formulaStructure formula
              Purity≥95% by HPLC
              SolubilityDMSO (5 mg/ml)
              Storage +2°C to +8°C
              Protect from light
              Do Not Freeze Ok to freeze
              Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 4 months at -20°C.
              Toxicity Irritant
              ReferencesFan, G.H., et al. 1999. Mol. Pharmacol. 56, 39.
              Tombes, R.M., et al. 1995. Cell Growth Differ. 6, 1063.
              Mamiya, N., et al. 1993. Biochem. Biophys. Res. Commun. 195, 608.
              Nicki, I., et al. 1993. Biochem. Biophys. Res. Commun. 191, 255.
              Sumi, M., et al. 1991. Biochem. Biophys. Res. Commun. 181, 968.
              Tokumitsu, H., et al. 1990. J. Biol. Chem. 265, 4315.

              Related Products & Applications

              Alternative Products

              Catalog Number Description  
              422711 KN-93, Water-Soluble - Calbiochem Show Pricing & Availability

              Categories

              Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Protein Phosphorylation / Dephosphorylation > Calmodulin-Dependent Protein Kinase (CaM Kinase) Inhibitors