420136 JNK Inhibitor IX - CAS 312917-14-9 - Calbiochem

420136
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₂₀H₁₆N₂OS • H₂O 312917-14-9

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      420136-5MG
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          Plastic ampoule 5 mg
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          Description
          OverviewA thienylnaphthamide compound that acts as a potent and ATP binding site-targeting inhibitor of JNK2 and JNK3 (pIC50 = 6.5 and 6.7, respectively) with little or no activity against JNK1, p38α, and a panel of more than 30 other kinases (pIC50 <5.0). In contrast, SP600125 (Cat. Nos. 420119 and 420128) offers little selectivity between JNK1 and JNK3 (pIC50 = 6.4 and 5.9, respectively) under the same assay conditions.
          Catalogue Number420136
          Brand Family Calbiochem®
          SynonymsN-(3-Cyano-4,5,6,7-tetrahydro-1-benzothien-2-yl)-1-naphthamide
          References
          ReferencesAngell, R.M., et al. 2007. Bioorg. Med. Chem. Lett. 17, 1296.
          Product Information
          CAS number312917-14-9
          ATP CompetitiveY
          FormTan solid
          Hill FormulaC₂₀H₁₆N₂OS • H₂O
          Chemical formulaC₂₀H₁₆N₂OS • H₂O
          ReversibleN
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Primary TargetJNK2 and JNK3
          Primary Target IC<sub>50</sub>pIC50 = 6.5 and 6.7, against JNK2 and JNK3, respectively
          Purity≥95% by HPLC
          Physicochemical Information
          Cell permeableN
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          R PhraseR: 36/37/38

          Irritating to eyes, respiratory system and skin.
          S PhraseS: 26-36-45

          In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
          Wear suitable protective clothing.
          In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Irritant
          Storage +2°C to +8°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          420136

          References

          Reference overview
          Angell, R.M., et al. 2007. Bioorg. Med. Chem. Lett. 17, 1296.

          Brochure

          Title
          Biologics 33.2
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision05-October-2007 JSW
          SynonymsN-(3-Cyano-4,5,6,7-tetrahydro-1-benzothien-2-yl)-1-naphthamide
          DescriptionA thienylnaphthamide compound that acts as a potent and ATP binding site-targeting inhibitor of JNK2 and JNK3 (pIC50 = 6.5 and 6.7, respectively) with little or no activity against JNK1, p38α, and a panel of more than 30 other kinases (pIC50 <5.0). In contrast, SP600125 (Cat. Nos. 420119 and 420128) offers little selectivity between JNK1 and JNK3 (pIC50 = 6.4 and 5.9, respectively) under the same assay conditions.
          FormTan solid
          Intert gas (Yes/No) Packaged under inert gas
          CAS number312917-14-9
          Chemical formulaC₂₀H₁₆N₂OS • H₂O
          Structure formulaStructure formula
          Purity≥95% by HPLC
          SolubilityDMSO (10 mg/ml)
          Storage +2°C to +8°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
          Toxicity Irritant
          ReferencesAngell, R.M., et al. 2007. Bioorg. Med. Chem. Lett. 17, 1296.