420104 JAK3 Inhibitor II - CAS 211555-04-3 - Calbiochem

420104
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₁₆H₁₄BrN₃O₃ 211555-04-3

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      420104-5MG
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          Plastic ampoule 5 mg
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          Description
          OverviewA potent, cell-permeable, reversible, ATP-competitive, and specific inhibitor of JAK3 (IC50 = 5.6 µM). Has no effect on either JAK1 or JAK2. Has also been shown to prevent the ionizing radiation-induced activation of c-Jun in DT-40 cells. Also acts as a potent inhibitor of glioblastoma cell adhesion and migration.
          Catalogue Number420104
          Brand Family Calbiochem®
          Synonyms4-[(3ʹ-Bromo-4ʹ-hydroxyphenyl)amino]-6,7-dimethoxyquinazoline, WHI-P154
          References
          ReferencesGhosh, S., et al. 2001. Acta Crystallogr. C. 57, 76.
          Sudbeck, E.A., et al. 1999. Clin. Cancer Res. 5, 1569.
          Goodman, P.A., et al. 1998. J. Biol. Chem. 273, 17742.
          Narla, R.K., et al. 1998. Clin Cancer Res. 4, 2463.
          Product Information
          CAS number211555-04-3
          ATP CompetitiveY
          FormPale yellow solid
          Hill FormulaC₁₆H₁₄BrN₃O₃
          Chemical formulaC₁₆H₁₄BrN₃O₃
          ReversibleY
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Primary TargetJAK-3
          Primary Target IC<sub>50</sub>5.6 µM against JAK3
          Purity≥97% by HPLC
          Physicochemical Information
          Cell permeableY
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage -20°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          420104

          References

          Reference overview
          Ghosh, S., et al. 2001. Acta Crystallogr. C. 57, 76.
          Sudbeck, E.A., et al. 1999. Clin. Cancer Res. 5, 1569.
          Goodman, P.A., et al. 1998. J. Biol. Chem. 273, 17742.
          Narla, R.K., et al. 1998. Clin Cancer Res. 4, 2463.

          Technical Info

          Title
          JAK/STAT Signaling Research Focus
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision12-January-2010 RFH
          Synonyms4-[(3ʹ-Bromo-4ʹ-hydroxyphenyl)amino]-6,7-dimethoxyquinazoline, WHI-P154
          DescriptionA potent, cell-permeable, reversible, ATP-competitive, and specific inhibitor of JAK3. Has no effect on either JAK1 or JAK2. Has also been shown to prevent the ionizing radiation-induced activation of c-jun in DT-40 cells.
          FormPale yellow solid
          Intert gas (Yes/No) Packaged under inert gas
          CAS number211555-04-3
          Chemical formulaC₁₆H₁₄BrN₃O₃
          Structure formulaStructure formula
          Purity≥97% by HPLC
          SolubilityDMSO (100 mg/ml)
          Storage -20°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Standard Handling
          ReferencesGhosh, S., et al. 2001. Acta Crystallogr. C. 57, 76.
          Sudbeck, E.A., et al. 1999. Clin. Cancer Res. 5, 1569.
          Goodman, P.A., et al. 1998. J. Biol. Chem. 273, 17742.
          Narla, R.K., et al. 1998. Clin Cancer Res. 4, 2463.