420139 JAK2 Inhibitor IV - CAS 1110502-30-1 - Calbiochem

420139
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₁₇H₂₀N₄O₂S 1110502-30-1

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      420139-5MG
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          Plastic ampoule 5 mg
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          Description
          OverviewAn aminoindazole compound that potently inhibits the activity of both the wild-type JAK2 and the constitutively active V617F mutant (IC50 = 78 and 206 nM, respectively) frequently found in patients with clonal polycythemia vera, essential thrombocytosis, and chronic idiopathic myelofibrosis, while exhibiting much reduced activity against JAK3 (IC50 = 2.93 µM).
          Catalogue Number420139
          Brand Family Calbiochem®
          Synonyms3-Amino-5-(N-tert-butylsulfonamido-4-phenyl)-indazole
          References
          ReferencesAntonysamy, S., et al. 2008. Bioorg. Med. Chem. Lett. 19, 279.
          Product Information
          CAS number1110502-30-1
          FormPale yellow solid
          Hill FormulaC₁₇H₂₀N₄O₂S
          Chemical formulaC₁₇H₂₀N₄O₂S
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Purity≥97% by HPLC
          Physicochemical Information
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage +2°C to +8°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          420139

          References

          Reference overview
          Antonysamy, S., et al. 2008. Bioorg. Med. Chem. Lett. 19, 279.

          Brochure

          Title
          Pathways and Biomarkers of JAK/STAT Signaling

          Technical Info

          Title
          JAK/STAT Signaling Research Focus
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision13-April-2011 RFH
          Synonyms3-Amino-5-(N-tert-butylsulfonamido-4-phenyl)-indazole
          DescriptionAn aminoindazole compound that potently inhibits the activity of both the wild-type JAK2 and the constitutively active V617F mutant (IC50 = 78 and 206 nM, respectively) frequently found in patients with clonal polycythemia vera, essential thrombocytosis, and chronic idiopathic myelofibrosis, while exhibiting much reduced activity against JAK3 (IC50 = 2.93 µM).
          FormPale yellow solid
          Intert gas (Yes/No) Packaged under inert gas
          CAS number1110502-30-1
          Chemical formulaC₁₇H₂₀N₄O₂S
          Structure formulaStructure formula
          Purity≥97% by HPLC
          SolubilityDMSO (5 mg/ml) or Ethanol (3 mg/ml)
          Storage +2°C to +8°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Standard Handling
          ReferencesAntonysamy, S., et al. 2008. Bioorg. Med. Chem. Lett. 19, 279.