416157 | Isohelenin, Inula sp. - Calbiochem

A cell-permeable sesquiterpene lactone with anti-inflammatory properties.

Isohelenin, <i>Inula</i> sp. - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: Isoalantolactone

Primary Target: NF-κB activation
416157
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical Formula
      C₁₅H₂₀O₂

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      416157-1MG
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          		Plastic ampoule 1 mg
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          Description
          OverviewA cell-permeable sesquiterpene lactone with anti-inflammatory properties. Acts as a highly specific, potent, irreversible inhibitor of NF-κB activation that acts by preventing IκBα degradation. Does not affect the DNA binding activity of activated NF-κB, or inhibit p59fyn and Src kinase activities. Inhibits IL-8 gene expression in cultured human respiratory epithelium in vitro, and iNOS gene expression in cultured rat aortic smooth muscle cells. Offers protection against endotoxic shock in vivo.
          Catalogue Number416157
          Brand Family Calbiochem®
          SynonymsIsoalantolactone
          References
          ReferencesSheehan, M., et al. 2002. J. Endotoxin. Res. 8, 99.
          Mazor, R.L., et al. 2000. Cytokine 12, 239.
          Wong. H.R., and Menendez, I.Y., 1999. Biochem. Biophys. Res. Commun. 262, 375.
          Hehner, S.P., et al. 1998. J. Biol. Chem. 273, 1288.
          Bork, P.M., et al. 1997. FEBS Lett. 402, 85.
          Product Information
          ATP CompetitiveN
          FormWhite solid
          Hill FormulaC₁₅H₂₀O₂
          Chemical formulaC₁₅H₂₀O₂
          ReversibleN
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Primary TargetNF-κB activation
          Purity≥95% by HPLC
          Physicochemical Information
          Cell permeableY
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Blue Ice Only
          Toxicity Standard Handling
          Storage -20°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          416157

          References

          Reference overview
          Sheehan, M., et al. 2002. J. Endotoxin. Res. 8, 99.
          Mazor, R.L., et al. 2000. Cytokine 12, 239.
          Wong. H.R., and Menendez, I.Y., 1999. Biochem. Biophys. Res. Commun. 262, 375.
          Hehner, S.P., et al. 1998. J. Biol. Chem. 273, 1288.
          Bork, P.M., et al. 1997. FEBS Lett. 402, 85.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision24-July-2008 RFH
          SynonymsIsoalantolactone
          DescriptionA cell-permeable sesquiterpene lactone with anti-inflammatory properties. Acts as a highly specific, potent, and irreversible inhibitor of NF-κB activation by preventing IκBα degradation. Does not affect the DNA binding activity of activated NF-κB or inhibit Fyn and Src kinase activities. Also reported to inhibit IL-8 gene expression in cultured human respiratory epithelium and iNOS gene expression in cultured rat aortic smooth muscle cells. Shown to protect against endotoxic shock in rats.
          FormWhite solid
          Intert gas (Yes/No) Packaged under inert gas
          Chemical formulaC₁₅H₂₀O₂
          Structure formulaStructure formula
          Purity≥95% by HPLC
          SolubilityDMSO (100 mg/ml) or Ethanol (20 mg/ml)
          Storage -20°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
          Toxicity Standard Handling
          ReferencesSheehan, M., et al. 2002. J. Endotoxin. Res. 8, 99.
          Mazor, R.L., et al. 2000. Cytokine 12, 239.
          Wong. H.R., and Menendez, I.Y., 1999. Biochem. Biophys. Res. Commun. 262, 375.
          Hehner, S.P., et al. 1998. J. Biol. Chem. 273, 1288.
          Bork, P.M., et al. 1997. FEBS Lett. 402, 85.