407673 Interleukin-8, Human, Recombinant, E. coli

407673
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      Overview

      Replacement Information

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      407673-10UG
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          Plastic ampoule 10 μg
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          Description
          OverviewRecombinant, human interleukin-8 expressed in E. coli. A potent proinflammatory cytokine produced by monocytes, fibroblasts, and keratinocytes in response to stimulation by LPS, IL-1, or TNF-α, and by T lymphocytes in response to PHA stimulation. Induces adhesion of neutrophils to endothelial cells. A physiological initiator of chemotactic migration of leukocytes. May be involved in chronic inflammation. IL-8 acts as an angiogenic factor in human gastric carcinoma.
          Catalogue Number407673
          Brand Family Calbiochem®
          SynonymsrhIL-8
          References
          ReferencesKido, S., et al. 2001. Eur. J. Cancer 37, 1482.
          Wilson, A.J., et al. 1999. Clin. Sci. 97, 385.
          Harada, A., et al. 1994. J. Leukoc. Biol. 56, 559.
          Mazzucchelli, L., et al. 1994. Am. J. Pathol. 144, 997.
          Oppenheim, J.J., et al. 1991. Annu. Rev. Immunol. 9, 617.
          Matsushima, K., et al. 1988. J. Exp. Med. 167, 1883.
          Schröeder, J., et al. 1987. J. Immunol. 139, 3474.
          Product Information
          FormLyophilized
          Applications
          Biological Information
          Biological activityED₅₀ = 150-300 ng/ml as measured by induction of myeloperoxidase release from human neutrophils
          Purity≥97% by SDS-PAGE
          Physicochemical Information
          ContaminantsEndotoxin: ≤100 EU/µg IL-8
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage ≤ -70°C
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-70°C) for long term storage or refrigerate (4°C) for short-term storage. Stock solutions are stable for up to 1 month at 4°C or up to 3 months at -70°C. Avoid freeze/thaw cycles of solutions.
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          407673

          References

          Reference overview
          Kido, S., et al. 2001. Eur. J. Cancer 37, 1482.
          Wilson, A.J., et al. 1999. Clin. Sci. 97, 385.
          Harada, A., et al. 1994. J. Leukoc. Biol. 56, 559.
          Mazzucchelli, L., et al. 1994. Am. J. Pathol. 144, 997.
          Oppenheim, J.J., et al. 1991. Annu. Rev. Immunol. 9, 617.
          Matsushima, K., et al. 1988. J. Exp. Med. 167, 1883.
          Schröeder, J., et al. 1987. J. Immunol. 139, 3474.

          Brochure

          Title
          Biologics 32.3 PDF ( 927 KB )
          Growth Factors and Cytokines Technical Bulletin

          Citations

          Title
        • Felicity J. Ashcroft, et al. (2004) Control of expression of the lectin-like protein Reg-1 by gastrin: role of the Rho family GTPase RhoA and a C-rich promoter element. Biochemical Journal 381, 397-403.
        • Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision14-July-2008 RFH
          SynonymsrhIL-8
          DescriptionRecombinant, human interleukin-8 expressed in E. coli. IL-8 is produced by monocytes, fibroblasts, and keratinocytes in response to stimulation by LPS, IL-1, or TNFα, and by T lymphocytes in response to PHA stimulation. Induces adhesion of neutrophils to endothelial cells. May be involved in chronic inflammation.
          FormLyophilized
          Purity≥97% by SDS-PAGE
          ContaminantsEndotoxin: ≤100 EU/µg IL-8
          Biological activityED₅₀ = 150-300 ng/ml as measured by induction of myeloperoxidase release from human neutrophils
          SolubilityReconstitute to a concentration ≥10 µg/ml with sterile PBS containing at least 0.1% HSA or BSA.
          Storage ≤ -70°C
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-70°C) for long term storage or refrigerate (4°C) for short-term storage. Stock solutions are stable for up to 1 month at 4°C or up to 3 months at -70°C. Avoid freeze/thaw cycles of solutions.
          Toxicity Standard Handling
          ReferencesKido, S., et al. 2001. Eur. J. Cancer 37, 1482.
          Wilson, A.J., et al. 1999. Clin. Sci. 97, 385.
          Harada, A., et al. 1994. J. Leukoc. Biol. 56, 559.
          Mazzucchelli, L., et al. 1994. Am. J. Pathol. 144, 997.
          Oppenheim, J.J., et al. 1991. Annu. Rev. Immunol. 9, 617.
          Matsushima, K., et al. 1988. J. Exp. Med. 167, 1883.
          Schröeder, J., et al. 1987. J. Immunol. 139, 3474.
          Citation
        • Felicity J. Ashcroft, et al. (2004) Control of expression of the lectin-like protein Reg-1 by gastrin: role of the Rho family GTPase RhoA and a C-rich promoter element. Biochemical Journal 381, 397-403.