407272 | Integrin αvβ3 Antagonist, P11 - Calbiochem

407272
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical Formula
      C₃₀H₅₁N₁₂O₉₃· 3TFA

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      407272-5MG
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      Stocked 
      Discontinued
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      Available
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          Glass bottle 5 mg
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          Description
          OverviewA cell-permeable, hexapeptide containing a novel integrin-binding motif, SDV (a Type I PDZ-binding motif) that is shown to compete with vitronectin for the RGD-binding site of integrin αvβ3 (IC50 = 1.74 pg/ml), in a chip-based assay. It is rapidly internalized into HUVECs, but not in NIH 3T3 cells, at a culture temperature of 37 °C, a process which is mediated by caveolin and clathrin. At 10 µg/ml, this compound is shown to significantly inhibit the phosphorylation of ERK1/2 and MEK in HUVECs. Furthermore, it suppresses bFGF-induced proliferation of HUVECs, dose-dependently, and displays up-regulation of p53 and induction of apoptosis via activation of caspases-3, -8 and -9 at 50 µg/ml.
          Catalogue Number407272
          Brand Family Calbiochem®
          SynonymsHSDVHK-NH2, HSDVHK
          References
          ReferencesBang, J., et al. 2011. Mol Cell Proteomics 10, M110.
          Choi, Y., et al. 2010. Proteomics 10, 72.
          Lee, Y., et al. 2004. J. Biomol. Screen. 9, 687.
          Product Information
          FormWhite solid
          FormulationSupplied as a trifluoracetate salt.
          Hill FormulaC₃₀H₅₁N₁₂O₉₃· 3TFA
          Chemical formulaC₃₀H₅₁N₁₂O₉₃· 3TFA
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Purity≥95% by HPLC
          Physicochemical Information
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Shipped with Blue Ice or with Dry Ice
          Toxicity Standard Handling
          Storage -20°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          407272

          References

          Reference overview
          Bang, J., et al. 2011. Mol Cell Proteomics 10, M110.
          Choi, Y., et al. 2010. Proteomics 10, 72.
          Lee, Y., et al. 2004. J. Biomol. Screen. 9, 687.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision27-jul-2012
          SynonymsHSDVHK-NH2, HSDVHK
          DescriptionA cell-permeable, hexapeptide containing a novel integrin-binding motif, SDV (a Type I PDZ-binding motif) that is shown to compete with vitronectin for the RGD-binding site of integrin αvβ3 (IC50 = 1.74 pg/ml), in a chip-based assay. It is rapidly internalized into HUVECs, but not in NIH 3T3 cells, at a culture temperature of 37 °C, a process which is mediated by caveolin and clathrin. At 10 µg/ml, this compound is shown to significantly inhibit the phosphorylation of ERK1/2 and MEK in HUVECs. Furthermore, it suppresses bFGF-induced proliferation of HUVECs, dose-dependently, and displays up-regulation of p53 and induction of apoptosis via activation of caspases-3, -8 and -9 at 50 µg/ml.
          FormWhite solid
          FormulationSupplied as a trifluoracetate salt.
          Intert gas (Yes/No) Packaged under inert gas
          Chemical formulaC₃₀H₅₁N₁₂O₉₃· 3TFA
          Structure formulaStructure formula
          Purity≥95% by HPLC
          SolubilityH₂O (100 mg/ml)
          Storage -20°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Standard Handling
          ReferencesBang, J., et al. 2011. Mol Cell Proteomics 10, M110.
          Choi, Y., et al. 2010. Proteomics 10, 72.
          Lee, Y., et al. 2004. J. Biomol. Screen. 9, 687.