559397 InSolution™ SB 202190 - CAS 152121-30-7 - Calbiochem

559397
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₂₀H₁₄FN₃O 152121-30-7

      Pricing & Availability

      Catalog Number AvailabilityPackaging Qty/Pack Price Quantity
      559397-1ML
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          Glass bottle 1 ml
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          Description
          Catalogue Number559397
          Brand Family Calbiochem®
          SynonymsInSolution™ p38 MAP Kinase Inhibitor II
          References
          ReferencesAjizian, S.J., et al. 1999. J. Infect. Dis. 179, 939.
          Singh, R.P., et al. 1999. J. Biol. Chem. 274, 19593.
          Wang, S.W., et al. 1999. Inflamm. Res. 48, 533.
          Gallagher, T.F., et al. 1997. Bioorg. Med. Chem. 5, 49.
          Jiang, Y., et al. 1996. J. Biol. Chem. 271, 17920.
          Kramer, R.M., et al. 1996. J. Biol. Chem. 271, 27723.
          Li, Z., et al. 1996. Biochem. Biophys. Res. Commun. 228, 334.
          Lee, L.C., et al. 1994. Nature 372, 739.
          Product Information
          CAS number152121-30-7
          ATP CompetitiveY
          FormLiquid
          FormulationA 1 mg/ml solution of SB 202190 (Cat. No. 559388) in anhydrous DMSO.
          Hill FormulaC₂₀H₁₄FN₃O
          Chemical formulaC₂₀H₁₄FN₃O
          ReversibleY
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Primary TargetP38β
          Primary Target IC<sub>50</sub>16 nM
          Primary Target K<sub>i</sub>16 nM; 350 nM against the kinase activity of p38β; 280 nM against p38 phosphorylation of activating transcription factor 2 (ATF-2)
          Purity≥98% by HPLC
          Concentration Label Please refer to vial label for lot-specific concentration
          Physicochemical Information
          Cell permeableY
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          R PhraseR: 36/37/38

          Irritating to eyes, respiratory system and skin.
          S PhraseS: 26-36

          In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
          Wear suitable protective clothing.
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Blue Ice Only
          Toxicity Irritant
          Storage -20°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C).
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          InSolution™ SB 202190 - CAS 152121-30-7 - Calbiochem SDS

          Title

          Safety Data Sheet (SDS) 

          InSolution™ SB 202190 - CAS 152121-30-7 - Calbiochem Certificates of Analysis

          TitleLot Number
          559397

          References

          Reference overview
          Ajizian, S.J., et al. 1999. J. Infect. Dis. 179, 939.
          Singh, R.P., et al. 1999. J. Biol. Chem. 274, 19593.
          Wang, S.W., et al. 1999. Inflamm. Res. 48, 533.
          Gallagher, T.F., et al. 1997. Bioorg. Med. Chem. 5, 49.
          Jiang, Y., et al. 1996. J. Biol. Chem. 271, 17920.
          Kramer, R.M., et al. 1996. J. Biol. Chem. 271, 27723.
          Li, Z., et al. 1996. Biochem. Biophys. Res. Commun. 228, 334.
          Lee, L.C., et al. 1994. Nature 372, 739.

          Brochure

          Title
          In Solution!" Product Flyer
          MAPK Pathway Poster ( 750 KB )

          Citations

          Title
        • Patrick Michl, et al. (2005) CUTL1 is a target of TGFβ signaling that enhances cancer cell motility and invasiveness. Cancer Cell 7, 521-532.
        • Yung-Luen Yu, et al. (2005) MAP kinase-mediated phosphorylation of GATA-1 promotes Bcl-XL expression and cell survival. Journal of Biological Chemistry 280, 29533-29542.
        • Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision07-April-2008 RFH
          SynonymsInSolution™ p38 MAP Kinase Inhibitor II
          DescriptionA potent and cell-permeable inhibitor of p38 MAP kinase. Inhibits p38 phosphorylation of myelin basic protein (MBP) with no effect on the activity of the ERK or JNK MAP kinase subgroups. Also inhibits the kinase activity of p38β (IC50 = 350 nM) and p38 phosphorylation of activating transcription factor 2 (ATF-2; IC50 = 280 nM). Blocks LPS-induced TNF-α and interleukin biosynthesis. Reported to block LDL expression in Hep52 cells.
          FormLiquid
          FormulationA 1 mg/ml solution of SB 202190 (Cat. No. 559388) in anhydrous DMSO.
          Intert gas (Yes/No) Packaged under inert gas
          Concentration Label Please refer to vial label for lot-specific concentration
          CAS number152121-30-7
          Chemical formulaC₂₀H₁₄FN₃O
          Structure formulaStructure formula
          Purity≥98% by HPLC
          Storage -20°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C).
          Toxicity Irritant
          ReferencesAjizian, S.J., et al. 1999. J. Infect. Dis. 179, 939.
          Singh, R.P., et al. 1999. J. Biol. Chem. 274, 19593.
          Wang, S.W., et al. 1999. Inflamm. Res. 48, 533.
          Gallagher, T.F., et al. 1997. Bioorg. Med. Chem. 5, 49.
          Jiang, Y., et al. 1996. J. Biol. Chem. 271, 17920.
          Kramer, R.M., et al. 1996. J. Biol. Chem. 271, 27723.
          Li, Z., et al. 1996. Biochem. Biophys. Res. Commun. 228, 334.
          Lee, L.C., et al. 1994. Nature 372, 739.
          Citation
        • Patrick Michl, et al. (2005) CUTL1 is a target of TGFβ signaling that enhances cancer cell motility and invasiveness. Cancer Cell 7, 521-532.
        • Yung-Luen Yu, et al. (2005) MAP kinase-mediated phosphorylation of GATA-1 promotes Bcl-XL expression and cell survival. Journal of Biological Chemistry 280, 29533-29542.