539161 InSolution™ Proteasome Inhibitor I - Calbiochem

539161
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical Formula
      C₃₂H₅₀N₄O₈

      Pricing & Availability

      Catalog Number AvailabilityPackaging Qty/Pack Price Quantity
      539161-5MG
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      Stocked 
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      Available
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          Plastic ampoule 5 mg
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          Description
          Catalogue Number539161
          Brand Family Calbiochem®
          SynonymsPSI
          References
          ReferencesGriscavage, J.M., et al. 1996. Proc. Natl. Acad. Sci. USA 93, 3308.
          Mori, S., et al. 1995. J. Biol. Chem. 270, 29447.
          Figueiredo-Pereira, M.E., et al. 1994. J. Neurochem. 63, 1578.
          Traenckner, E.B., et al. 1994. EMBO J. 13, 5433.
          Product Information
          ATP CompetitiveN
          FormLiquid
          FormulationA 50 mM (5 mg/162 µl) solution of Proteasome Inhibitor I (Cat. No. 539160) in DMSO.
          Hill FormulaC₃₂H₅₀N₄O₈
          Chemical formulaC₃₂H₅₀N₄O₈
          Hygroscopic Hygroscopic
          ReversibleN
          Applications
          Biological Information
          Primary Targetchymotrypsin-like activity of the multicatalytic proteinase complex (MCP; 20S proteasome) in HT4 cells
          Purity≥90% by HPLC
          Physicochemical Information
          Cell permeableN
          Peptide SequenceZ-Ile-Glu(OtBu)-Ala-Leu-CHO
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Shipped with Blue Ice or with Dry Ice
          Toxicity Irritant
          Storage -20°C
          Protect from Light Protect from light
          Hygroscopic Hygroscopic
          Do not freeze Ok to freeze
          Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C).
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          InSolution™ Proteasome Inhibitor I - Calbiochem SDS

          Title

          Safety Data Sheet (SDS) 

          InSolution™ Proteasome Inhibitor I - Calbiochem Certificates of Analysis

          TitleLot Number
          539161

          References

          Reference overview
          Griscavage, J.M., et al. 1996. Proc. Natl. Acad. Sci. USA 93, 3308.
          Mori, S., et al. 1995. J. Biol. Chem. 270, 29447.
          Figueiredo-Pereira, M.E., et al. 1994. J. Neurochem. 63, 1578.
          Traenckner, E.B., et al. 1994. EMBO J. 13, 5433."

          Brochure

          Title
          In Solution!" Product Flyer
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision04-September-2008 RFH
          SynonymsPSI
          DescriptionCell-permeable inhibitor of the chymotrypsin-like activity of the multicatalytic proteinase complex (MCP; 20S proteasome) in HT4 cells. Causes the accumulation of ubiquitinated proteins in neuronal cells. Prevents NF-κB activation in response to TNFα and okadaic acid through inhibition of IκBα degradation, thereby interfering with induction of iNOS in macrophages.
          FormLiquid
          FormulationA 50 mM (5 mg/162 µl) solution of Proteasome Inhibitor I (Cat. No. 539160) in DMSO.
          Intert gas (Yes/No) Packaged under inert gas
          Chemical formulaC₃₂H₅₀N₄O₈
          Peptide SequenceZ-Ile-Glu(OtBu)-Ala-Leu-CHO
          Purity≥90% by HPLC
          Storage -20°C
          Hygroscopic
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C).
          Toxicity Irritant
          ReferencesGriscavage, J.M., et al. 1996. Proc. Natl. Acad. Sci. USA 93, 3308.
          Mori, S., et al. 1995. J. Biol. Chem. 270, 29447.
          Figueiredo-Pereira, M.E., et al. 1994. J. Neurochem. 63, 1578.
          Traenckner, E.B., et al. 1994. EMBO J. 13, 5433.