495609 InSolution™ Okadaic Acid, Prorocentrum sp. - Calbiochem

495609
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical Formula
      C₄₄H₆₈O₁₃

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      495609-25UG
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      Limited AvailabilityLimited Availability
      Stocked 
      Discontinued
      Limited Quantities Available
      Available
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          Plastic Bag(s) 25 μg
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          Description
          Catalogue Number495609
          Brand Family Calbiochem®
          References
          ReferencesGjertsen, B.T., et al. 1994. J. Cell Sci. 107, 3363.
          Kiguchi, K., et al. 1994. Cell Growth Differentiation 5, 995.
          Ohaka, Y., et al. 1993. Biochem. Biophys. Res. Commun. 197, 916.
          Gopalakrishna, R., et al. 1992. Biochem. Biophys. Res. Commun. 189, 950.
          Kreienbuhl, P., et al. 1992. Blood 80, 2911.
          Nomura, M., et al. 1992. Biochemistry 31, 11915.
          Song, Q., et al. 1992. J. Cell Physiol. 153, 550.
          Tada, Y., et al. 1992. Immunopharmacol. 24, 17.
          Cohen, P., et al. 1990. Trends Biochem. Sci. 15, 98.
          Cohen, P. 1989. Annu. Rev. Biochem. 58, 453.
          Cohen, P., and Cohen, P.T. 1989. J. Biol. Chem. 264, 21435.
          Haystead, T.A., et al. 1989. Nature 337, 78.
          Product Information
          ATP CompetitiveN
          FormLiquid
          FormulationA 250 µM (25 µg/124 µl) solution of Okadaic Acid, (Cat. No. 495604) in DMSO.
          Hill FormulaC₄₄H₆₈O₁₃
          Chemical formulaC₄₄H₆₈O₁₃
          Hygroscopic Hygroscopic
          ReversibleN
          Structure formula ImageStructure formula Image
          Applications
          ApplicationInSolution™ Okadaic Acid, Prorocentrum sp. CAS 78111-17-8, is a 250 µM solution of Okadaic Acid in DMSO. Potent inhibitor of protein phosphatase 1 (IC50 = 10-15 nM) and 2A (IC50 = 0.1 nM).
          Biological Information
          Primary Targetprotein phosphatase
          Primary Target IC<sub>50</sub>10-15 nM against protein phosphatase 1; 0.1 nM against protein phosphatase 2A
          Purity≥95% by HPLC
          Physicochemical Information
          Cell permeableN
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Blue Ice Only
          Toxicity Toxic
          Hazardous Materials Attention: Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
          Storage -20°C
          Protect from Light Protect from light
          Hygroscopic Hygroscopic
          Do not freeze Ok to freeze
          Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C).
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          495609

          References

          Reference overview
          Gjertsen, B.T., et al. 1994. J. Cell Sci. 107, 3363.
          Kiguchi, K., et al. 1994. Cell Growth Differentiation 5, 995.
          Ohaka, Y., et al. 1993. Biochem. Biophys. Res. Commun. 197, 916.
          Gopalakrishna, R., et al. 1992. Biochem. Biophys. Res. Commun. 189, 950.
          Kreienbuhl, P., et al. 1992. Blood 80, 2911.
          Nomura, M., et al. 1992. Biochemistry 31, 11915.
          Song, Q., et al. 1992. J. Cell Physiol. 153, 550.
          Tada, Y., et al. 1992. Immunopharmacol. 24, 17.
          Cohen, P., et al. 1990. Trends Biochem. Sci. 15, 98.
          Cohen, P. 1989. Annu. Rev. Biochem. 58, 453.
          Cohen, P., and Cohen, P.T. 1989. J. Biol. Chem. 264, 21435.
          Haystead, T.A., et al. 1989. Nature 337, 78.

          Brochure

          Title
          In Solution!" Product Flyer

          Citations

          Title
        • Mike T. Lin, et al. (2005) Ca2+-activated K+ channel-associated phosphatase and kinase activities during development. American Journal of Physiology Heart and Circulatory Physiology 289, H414-H425.
        • Ramesh M. Ray, Sujoy bhattacharya and Leonard R. Johnson. (2005) Protein phosphatase 2A (PP2A) regulates apoptosis in IEC-6 cells. Journal of Biological Chemistry 280, 31091-31100.
        • Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision13-March-2009 RFH
          DescriptionAn ionophore-like polyether derivative of a C38 fatty acid compound isolated from dinoflagellates that have fed on the marine sponge Halinchrondria okadai. It is a potent non-comepetitive, reversible inhibitor of serine/threonine-specific protein phosphatases 1 (PP1, IC50 = 10-15 nM, rabbit skeletal muscle, catalytic subunit) and 2A (PP2A, IC50 = 0.1 nM, rabbit skeletal muscle, catalytic subunit). It has only a trivial effect on protein phosphatase 2B (IC50 = 5 µM), a Ca2+/calmodulin-dependent enzyme, while PP2C, a Mg2+ dependent enzyme, is unaffected. Okadaic acid has no significant effect on the activities of tyrosine phosphatases, alkaline phosphatase, acid phosphatase, and inositol trisphosphatase. It is also a non-phorbol ester-type tumor promoter on mouse skin. Useful for the study of protein phosphatases and of PP1/PP2A in cell extracts, as well as in intact cells. Induces apoptosis in human breast carcinoma (MB-231 and MCF-7) and in myeloid cells, but inhibits glucocorticoid-induced apoptosis in T-cell hybridomas. Has marked contractile effect on smooth muscles and heart muscles. Implicated as a causative agent of diarrhetic shellfish poisoning.
          FormLiquid
          FormulationA 250 µM (25 µg/124 µl) solution of Okadaic Acid, (Cat. No. 495604) in DMSO.
          Intert gas (Yes/No) Packaged under inert gas
          Chemical formulaC₄₄H₆₈O₁₃
          Structure formulaStructure formula
          Purity≥95% by HPLC
          Storage -20°C
          Hygroscopic
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C).
          Toxicity Toxic
          Merck USA index14, 6819
          ReferencesGjertsen, B.T., et al. 1994. J. Cell Sci. 107, 3363.
          Kiguchi, K., et al. 1994. Cell Growth Differentiation 5, 995.
          Ohaka, Y., et al. 1993. Biochem. Biophys. Res. Commun. 197, 916.
          Gopalakrishna, R., et al. 1992. Biochem. Biophys. Res. Commun. 189, 950.
          Kreienbuhl, P., et al. 1992. Blood 80, 2911.
          Nomura, M., et al. 1992. Biochemistry 31, 11915.
          Song, Q., et al. 1992. J. Cell Physiol. 153, 550.
          Tada, Y., et al. 1992. Immunopharmacol. 24, 17.
          Cohen, P., et al. 1990. Trends Biochem. Sci. 15, 98.
          Cohen, P. 1989. Annu. Rev. Biochem. 58, 453.
          Cohen, P., and Cohen, P.T. 1989. J. Biol. Chem. 264, 21435.
          Haystead, T.A., et al. 1989. Nature 337, 78.
          Citation
        • Mike T. Lin, et al. (2005) Ca2+-activated K+ channel-associated phosphatase and kinase activities during development. American Journal of Physiology Heart and Circulatory Physiology 289, H414-H425.
        • Ramesh M. Ray, Sujoy bhattacharya and Leonard R. Johnson. (2005) Protein phosphatase 2A (PP2A) regulates apoptosis in IEC-6 cells. Journal of Biological Chemistry 280, 31091-31100.